STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
capPPutative phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (907 aa)    
Predicted Functional Partners:
eno
Putative enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity). Binds plasminogen and human salivary mucin MG2 when expressed on the bacterial cell surface, potentially allowing the bacterium to acquire surface-associated proteolytic activity that may help the dissemination through oral tissues and entrance into the blood stream; Belongs to the enolase family.
   
 
 0.927
pykF
Pyruvate kinase; Best Blastp Hit: gb|AAF25804.1|AF172173_2 (AF172173) pyruvate kinase [Streptococcus thermophilus].
   
 
 0.925
pckA
Best Blastp Hit: pir||D72755 hypothetical protein APE0033 - Aeropyrum pernix (strain K1) >gi|5103421|dbj|BAA78942.1| (AP000058) 493aa long hypothetical protein [Aeropyrum pernix].
   
 
 0.922
pycB
Putative pyruvate carboxylase/oxaloacetate decarboxylase, alpha subunit; Best Blastp Hit: sp|Q58628|PYCB_METJA PYRUVATE CARBOXYLASE SUBUNIT B (PYRUVIC CARBOXYLASE B) >gi|2129173|pir||F64453 oxaloacetate decarboxylase (EC 4.1.1.3) alpha chain MJ1231 [similarity] - Methanococcus jannaschii >gi|1591862|gb|AAB99233.1| (U67563) oxaloacetate decarboxylase alpha chain (oadA) [Methanococcus jannaschii].
   
 
 0.915
oadB
Putative oxaloacetate decarboxylase, sodium ion pump subunit; Tunnel subunit of the primary sodium pump glutaconyl-CoA decarboxylase (GCD).
   
 
  0.900
citZ
Citrate synthase; Best Blastp Hit: sp|Q59939|CISZ_STRMU CITRATE SYNTHASE >gi|1421813|gb|AAC44825.1| (U62799) citrate synthase [Streptococcus mutans].
     
 0.843
SMU_1172c
Conserved hypothetical protein; Best Blastp Hit: emb|CAC11861.1| (AL445065) conserved hypothetical protein [Thermoplasma acidophilum].
     
  0.800
SMU_139
Best Blastp Hit: pir||E70047 conserved hypothetical protein yvrK - Bacillus subtilis >gi|2635821|emb|CAB15314.1| (Z99120) similar to hypothetical proteins [Bacillus subtilis] >gi|2635837|emb|CAB15329.1| (Z99121) similar to hypothetical proteins [Bacillus subtilis] >gi|2832803|emb|CAA11727.1| (AJ223978) YvrK protein [Bacillus subtilis].
     
  0.800
gltA
Best Blastp Hit: dbj|BAB05447.1| (AP001513) glutamate synthase (large subunit) [Bacillus halodurans].
  
  
 0.791
accD
Putative acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.
   
  
 0.686
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.