STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rpoDDNA-dependent RNA polymerase sigma subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (371 aa)    
Predicted Functional Partners:
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.997
rpoC
DNA-dependent RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.996
rpoB
DNA-dependent RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
 
 
 0.996
rpoZ
RNA polymerase-associated protein RpoZ, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
 
 0.994
dnaG
Putative DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
 
  
 0.978
nusA
Putative transcription factor NusA; Participates in both transcription termination and antitermination.
 
 
 0.799
SMU_823
Conserved hypothetical protein; Best Blastp Hit: dbj|BAA21508.1| (AB000631) unnamed protein product [Streptococcus mutans].
       0.777
SMU_1296
Putative glutathione S-transferase; Best Blastp Hit: pir||C65085 hypothetical protein b2989 - Escherichia coli (strain K-12) >gi|882518|gb|AAA69156.1| (U28377) ORF_o304; GTG start [Escherichia coli] >gi|1789363|gb|AAC76025.1| (AE000382) orf, hypothetical protein [Escherichia coli]; Belongs to the GST superfamily.
   
 
 0.755
dnaK
Heat shock protein, DnaK (HSP-70); Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.748
furR
Putative ferric uptake regulator protein FurR; Best Blastp Hit: gb|AAB18795.1| (U76538) Fur-like protein [Streptococcus pyogenes]; Belongs to the Fur family.
  
 
 0.711
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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