STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMU_843Conserved hypothetical protein; Best Blastp Hit: gi|10956446 pXO2-56 [Bacillus anthracis] >gi|6470207|gb|AAF13661.1|AF188935_59 (AF188935) pXO2-56 [Bacillus anthracis]. (393 aa)    
Predicted Functional Partners:
SMU_844
Best Blastp Hit: pir||C69843 hypothetical protein yjbC -## Bacillus subtilis >gi|2633503|emb|CAB13006.1| (Z99110) yjbC [Bacillus subtilis].
       0.710
SMU_2152c
Conserved hypothetical protein; Best Blastp Hit: gb|AAC61482.1| (AF082738) unknown [Streptococcus pyogenes].
     
 0.607
pyrK
Putative dihydroorotate dehydrogenase, electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
     
 0.604
SMU_1209c
Hypothetical protein; Best Blastp Hit: gi|6715600 golgi autoantigen, golgin subfamily a, 4; golgin 245; golgin-240; p230 [Homo sapiens] >gi|1213484|gb|AAC50434.1| (U41740) trans-Golgi p230 [Homo sapiens] >gi|1589554|prf||2211333A peripheral membrane protein p230 [Homo sapiens].
      
 0.599
SMU_521
Conserved hypothetical protein; Best Blastp Hit: dbj|BAB07152.1| (AP001518) unknown conserved protein in B. subtilis [Bacillus halodurans].
      
 0.599
SMU_845
Best Blastp Hit: pir||F69065 hypothetical protein MTH1490 - Methanobacterium thermoautotrophicum (strain Delta H) >gi|2622606|gb|AAB85965.1| (AE000909) unknown [Methanobacterium thermoautotrophicum].
       0.594
SMU_630
Hypothetical protein; Best Blastp Hit: emb|CAA67776.1| (X99400) D,D-carboxypeptidase [Streptococcus pneumoniae].
  
     0.582
thiI
Putative thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
       0.548
SMU_464
Putative nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
  
    0.536
SMU_1194
Best Blastp Hit: pir||G71842 probable ABC transporter, ATP-binding protein - Helicobacter pylori (strain J99) >gi|4155748|gb|AAD06727.1| (AE001542) putative ABC transporter, ATP-binding protein [Helicobacter pylori J99].
  
   
 0.517
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.