STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMU_941cConserved hypothetical protein; Best Blastp Hit: gi|6321402 Mtc2p [Saccharomyces cerevisiae] >gi|1723820|sp|P53185|MTC2_YEAST MTC2 PROTEIN >gi|2132524|pir||S64038 probable membrane protein YGL036w - yeast (Saccharomyces cerevisiae) >gi|1322516|emb|CAA96738.1| (Z72558) ORF YGL036w [Saccharomyces cerevisiae]. (113 aa)    
Predicted Functional Partners:
SMU_940c
Putative hemolysin III; Best Blastp Hit: sp|P54176|HLY3_BACCE HEMOLYSIN III (HLY-III) >gi|2126776|pir||S59967 hemolysin III - Bacillus cereus >gi|662880|emb|CAA58877.1| (X84058) novel hemolytic factor [Bacillus cereus].
  
  
 0.851
dnaJ
Heat shock protein DnaJ (HSP-40); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...]
  
 
 0.606
mvaA
Putative hydroxymethylglutaryl-CoA reductase; Best Blastp Hit: gb|AAG02449.1|AF290096_2 (AF290096) HMG-CoA reductase [Streptococcus pyogenes].
       0.486
SMU_943c
Putative hydroxymethylglutaryl-CoA synthase; Best Blastp Hit: gb|AAG02453.1|AF290098_1 (AF290098)## HMG-CoA synthase [Streptococcus pneumoniae].
       0.486
SMU_2146c
Hypothetical protein; Best Blastp Hit: gb|AAF66691.1|AF144681_1 (AF144681) immunodominant antigen A [Staphylococcus aureus].
  
     0.473
SMU_1723c
Best Blastp Hit: pir||B72201 conserved hypothetical protein - Thermotoga maritima (strain MSB8) >gi|4982442|gb|AAD36919.1|AE001823_1 (AE001823) conserved hypothetical protein [Thermotoga maritima].
 
 
   0.450
rpoB
DNA-dependent RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.435
rpoD
DNA-dependent RNA polymerase sigma subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
   
 
 0.423
SMU_630
Hypothetical protein; Best Blastp Hit: emb|CAA67776.1| (X99400) D,D-carboxypeptidase [Streptococcus pneumoniae].
  
     0.421
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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