node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDM19964.1 | SDM38622.1 | SAMN04489726_0319 | SAMN04489726_1366 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.967 |
SDM19964.1 | SDM52959.1 | SAMN04489726_0319 | SAMN04489726_2079 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Amino acid adenylation domain-containing protein. | 0.740 |
SDM19964.1 | SDM88819.1 | SAMN04489726_0319 | SAMN04489726_3851 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glutamate synthase (NADPH/NADH) large chain. | 0.546 |
SDM19964.1 | SDN30839.1 | SAMN04489726_0319 | SAMN04489726_5980 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hypothetical protein. | 0.709 |
SDM19964.1 | guaA | SAMN04489726_0319 | SAMN04489726_5072 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.596 |
SDM19964.1 | guaB | SAMN04489726_0319 | SAMN04489726_5080 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.797 |
SDM38622.1 | SDM19964.1 | SAMN04489726_1366 | SAMN04489726_0319 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.967 |
SDM38622.1 | SDM52959.1 | SAMN04489726_1366 | SAMN04489726_2079 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Amino acid adenylation domain-containing protein. | 0.740 |
SDM38622.1 | SDM88819.1 | SAMN04489726_1366 | SAMN04489726_3851 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glutamate synthase (NADPH/NADH) large chain. | 0.546 |
SDM38622.1 | SDN30839.1 | SAMN04489726_1366 | SAMN04489726_5980 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hypothetical protein. | 0.709 |
SDM38622.1 | guaA | SAMN04489726_1366 | SAMN04489726_5072 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.596 |
SDM38622.1 | guaB | SAMN04489726_1366 | SAMN04489726_5080 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.797 |
SDM49268.1 | SDM88819.1 | SAMN04489726_1899 | SAMN04489726_3851 | Component of the Tol biopolymer transport system. | Glutamate synthase (NADPH/NADH) large chain. | 0.888 |
SDM49268.1 | SDN30839.1 | SAMN04489726_1899 | SAMN04489726_5980 | Component of the Tol biopolymer transport system. | Hypothetical protein. | 0.519 |
SDM52959.1 | SDM19964.1 | SAMN04489726_2079 | SAMN04489726_0319 | Amino acid adenylation domain-containing protein. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.740 |
SDM52959.1 | SDM38622.1 | SAMN04489726_2079 | SAMN04489726_1366 | Amino acid adenylation domain-containing protein. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.740 |
SDM52959.1 | SDM86791.1 | SAMN04489726_2079 | SAMN04489726_3754 | Amino acid adenylation domain-containing protein. | Amino acid adenylation domain-containing protein. | 0.999 |
SDM52959.1 | SDM88819.1 | SAMN04489726_2079 | SAMN04489726_3851 | Amino acid adenylation domain-containing protein. | Glutamate synthase (NADPH/NADH) large chain. | 0.943 |
SDM52959.1 | SDN30839.1 | SAMN04489726_2079 | SAMN04489726_5980 | Amino acid adenylation domain-containing protein. | Hypothetical protein. | 0.579 |
SDM77122.1 | SDN30839.1 | SAMN04489726_3296 | SAMN04489726_5980 | WD40-like Beta Propeller Repeat. | Hypothetical protein. | 0.519 |