node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDM15634.1 | SDN00457.1 | SAMN04489726_0068 | SAMN04489726_4416 | Asparagine synthase (glutamine-hydrolysing). | Homoserine dehydrogenase. | 0.431 |
SDM15634.1 | SDN32397.1 | SAMN04489726_0068 | SAMN04489726_6056 | Asparagine synthase (glutamine-hydrolysing). | Aspartate kinase; Belongs to the aspartokinase family. | 0.910 |
SDM15634.1 | argG | SAMN04489726_0068 | SAMN04489726_3509 | Asparagine synthase (glutamine-hydrolysing). | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. | 0.894 |
SDM15634.1 | purA | SAMN04489726_0068 | SAMN04489726_5582 | Asparagine synthase (glutamine-hydrolysing). | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.890 |
SDM19964.1 | SDM38622.1 | SAMN04489726_0319 | SAMN04489726_1366 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.967 |
SDM19964.1 | SDN00457.1 | SAMN04489726_0319 | SAMN04489726_4416 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine dehydrogenase. | 0.950 |
SDM19964.1 | SDN32397.1 | SAMN04489726_0319 | SAMN04489726_6056 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aspartate kinase; Belongs to the aspartokinase family. | 0.931 |
SDM19964.1 | asd | SAMN04489726_0319 | SAMN04489726_6057 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.552 |
SDM19964.1 | dapF | SAMN04489726_0319 | SAMN04489726_7431 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.461 |
SDM19964.1 | metXA | SAMN04489726_0319 | SAMN04489726_3591 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.955 |
SDM19964.1 | thrB | SAMN04489726_0319 | SAMN04489726_4414 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.890 |
SDM38622.1 | SDM19964.1 | SAMN04489726_1366 | SAMN04489726_0319 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.967 |
SDM38622.1 | SDN00457.1 | SAMN04489726_1366 | SAMN04489726_4416 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine dehydrogenase. | 0.950 |
SDM38622.1 | SDN32397.1 | SAMN04489726_1366 | SAMN04489726_6056 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aspartate kinase; Belongs to the aspartokinase family. | 0.931 |
SDM38622.1 | asd | SAMN04489726_1366 | SAMN04489726_6057 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.552 |
SDM38622.1 | dapF | SAMN04489726_1366 | SAMN04489726_7431 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.461 |
SDM38622.1 | metXA | SAMN04489726_1366 | SAMN04489726_3591 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | 0.955 |
SDM38622.1 | thrB | SAMN04489726_1366 | SAMN04489726_4414 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.890 |
SDN00457.1 | SDM15634.1 | SAMN04489726_4416 | SAMN04489726_0068 | Homoserine dehydrogenase. | Asparagine synthase (glutamine-hydrolysing). | 0.431 |
SDN00457.1 | SDM19964.1 | SAMN04489726_4416 | SAMN04489726_0319 | Homoserine dehydrogenase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.950 |