Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
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[Homology]
Score
hrcAHrcA family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)    
Predicted Functional Partners:
grpE
Heat shock chaperone GrpE; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.976
dnaK
Molecular chaperone DnaK; Heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.653
clpB
ATP-dependent chaperone protein ClpB; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.643
dnaJ
Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.623
rpmE
50S ribosomal protein L31; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.508
rsmE
16S ribosomal RNA methyltransferase RsmE; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.487
rpsD
30S ribosomal protein S4; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.468
lepA
GTP-binding protein LepA; Back-translocating Elongation Factor EF4; binds to the ribosome on the universally-conserved alpha-sarcin loop; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.454
rsmI
Ribosomal RNA small subunit methyltransferase I; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.452
msrAB
Peptide methionine sulfoxide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.444
Your Current Organism:
Mycoplasma californicum
NCBI taxonomy Id: 2113
Other names: ATCC 33461, DSM 21477, M. californicum, NCTC 10189, strain ST-6
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