STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
grpEHeat shock chaperone GrpE; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)    
Predicted Functional Partners:
dnaK
Molecular chaperone DnaK; Heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.999
hrcA
HrcA family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.985
dnaJ
Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.976
clpB
ATP-dependent chaperone protein ClpB; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.924
msrAB
Peptide methionine sulfoxide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 
 0.802
AIA29775.1
5'-3' exonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.787
lon
ATP-dependent protease La; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.737
secA
Preprotein translocase subunit SecA; Functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, there are paralogous proteins that have [...]
  
  
 0.548
lepA
GTP-binding protein LepA; Back-translocating Elongation Factor EF4; binds to the ribosome on the universally-conserved alpha-sarcin loop; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.542
tig
Peptidylprolyl isomerase (trigger factor); Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.541
Your Current Organism:
Mycoplasma californicum
NCBI taxonomy Id: 2113
Other names: ATCC 33461, DSM 21477, M. californicum, NCTC 10189, strain ST-6
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