close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
secAPreprotein translocase subunit SecA; Functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, there are paralogous proteins that have [...] (850 aa)    
Predicted Functional Partners:
secG
Preprotein translocase subunit SecG; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.999
secY
Preprotein translocase subunit SecY; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.999
secDF
Bifunctional preprotein translocase subunit SecD/SecF; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
  
 
 0.994
yidC
Preprotein translocase subunit YidC; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.982
ffh
With 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.952
ftsY
Cell division protein FtsY; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.951
ftsZ
Cell division protein FtsZ; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.933
rplW
50S ribosomal protein L23; Binds third domain of 23S rRNA and protein L29; part of exit tunnel; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
   0.907
rpmC
50S ribosomal protein L29; One of the stabilizing components for the large ribosomal subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
   0.902
secE
Preprotein translocase subunit SecE; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.900
Your Current Organism:
Mycoplasma californicum
NCBI taxonomy Id: 2113
Other names: ATCC 33461, DSM 21477, M. californicum, NCTC 10189, strain ST-6
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.