| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| hemD | hemF | SO_4314 | SO_0038 | uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Aerobic coproporphyrinogen III oxidase HemF; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.651 |
| hemD | hemG | SO_4314 | SO_0025 | uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Oxygen-independent protoporphyrinogen oxidase HemG. | 0.736 |
| hemD | hemG-2 | SO_4314 | SO_0027 | uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Oxygen-independent protoporphyrinogen oxidase HemG. | 0.821 |
| hemD | hemG-3 | SO_4314 | SO_3720 | uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Oxygen-independent protoporphyrinogen oxidase HemG. | 0.748 |
| hemD | hemH | SO_4314 | SO_2019 | uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Ferrochelatase HemH; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.801 |
| hemD | hemH2 | SO_4314 | SO_3348 | uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Ferrochelatase HemH; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.771 |
| hemD | hemN | SO_4314 | SO_4730 | uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Coproporphyrinogen III oxidase oxygen-independent HemN; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.648 |
| hemD | hemX | SO_4314 | SO_4315 | uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | uroporphyrin-III C-methyltransferase HemX. | 0.994 |
| hemD | hmuX | SO_4314 | SO_3668 | uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Heme iron utilization protein HmuX. | 0.492 |
| hemF | hemD | SO_0038 | SO_4314 | Aerobic coproporphyrinogen III oxidase HemF; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.651 |
| hemF | hemG | SO_0038 | SO_0025 | Aerobic coproporphyrinogen III oxidase HemF; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Oxygen-independent protoporphyrinogen oxidase HemG. | 0.957 |
| hemF | hemG-2 | SO_0038 | SO_0027 | Aerobic coproporphyrinogen III oxidase HemF; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Oxygen-independent protoporphyrinogen oxidase HemG. | 0.950 |
| hemF | hemG-3 | SO_0038 | SO_3720 | Aerobic coproporphyrinogen III oxidase HemF; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Oxygen-independent protoporphyrinogen oxidase HemG. | 0.957 |
| hemF | hemH | SO_0038 | SO_2019 | Aerobic coproporphyrinogen III oxidase HemF; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Ferrochelatase HemH; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.857 |
| hemF | hemH2 | SO_0038 | SO_3348 | Aerobic coproporphyrinogen III oxidase HemF; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Ferrochelatase HemH; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.873 |
| hemF | hemN | SO_0038 | SO_4730 | Aerobic coproporphyrinogen III oxidase HemF; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Coproporphyrinogen III oxidase oxygen-independent HemN; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.988 |
| hemF | hmuX | SO_0038 | SO_3668 | Aerobic coproporphyrinogen III oxidase HemF; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | Heme iron utilization protein HmuX. | 0.518 |
| hemG | hemD | SO_0025 | SO_4314 | Oxygen-independent protoporphyrinogen oxidase HemG. | uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.736 |
| hemG | hemF | SO_0025 | SO_0038 | Oxygen-independent protoporphyrinogen oxidase HemG. | Aerobic coproporphyrinogen III oxidase HemF; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.957 |
| hemG | hemG-2 | SO_0025 | SO_0027 | Oxygen-independent protoporphyrinogen oxidase HemG. | Oxygen-independent protoporphyrinogen oxidase HemG. | 0.914 |