| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| hemA | hemB | SO_3834 | SO_2587 | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. | 0.956 |
| hemA | hemB-2 | SO_3834 | SO_4208 | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. | 0.951 |
| hemA | hemD | SO_3834 | SO_4314 | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.891 |
| hemA | hemF | SO_3834 | SO_0038 | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Aerobic coproporphyrinogen III oxidase HemF; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.874 |
| hemA | hemG | SO_3834 | SO_0025 | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Oxygen-independent protoporphyrinogen oxidase HemG. | 0.663 |
| hemA | hemG-2 | SO_3834 | SO_0027 | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Oxygen-independent protoporphyrinogen oxidase HemG. | 0.744 |
| hemA | hemG-3 | SO_3834 | SO_3720 | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Oxygen-independent protoporphyrinogen oxidase HemG. | 0.666 |
| hemA | hemH | SO_3834 | SO_2019 | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Ferrochelatase HemH; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.804 |
| hemA | hemH2 | SO_3834 | SO_3348 | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Ferrochelatase HemH; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.795 |
| hemA | hemN | SO_3834 | SO_4730 | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Coproporphyrinogen III oxidase oxygen-independent HemN; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.811 |
| hemB | hemA | SO_2587 | SO_3834 | Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.956 |
| hemB | hemB-2 | SO_2587 | SO_4208 | Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. | Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. | 0.913 |
| hemB | hemD | SO_2587 | SO_4314 | Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. | uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.923 |
| hemB | hemF | SO_2587 | SO_0038 | Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. | Aerobic coproporphyrinogen III oxidase HemF; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.732 |
| hemB | hemG | SO_2587 | SO_0025 | Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. | Oxygen-independent protoporphyrinogen oxidase HemG. | 0.653 |
| hemB | hemG-2 | SO_2587 | SO_0027 | Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. | Oxygen-independent protoporphyrinogen oxidase HemG. | 0.737 |
| hemB | hemG-3 | SO_2587 | SO_3720 | Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. | Oxygen-independent protoporphyrinogen oxidase HemG. | 0.667 |
| hemB | hemH | SO_2587 | SO_2019 | Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. | Ferrochelatase HemH; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.774 |
| hemB | hemH2 | SO_2587 | SO_3348 | Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. | Ferrochelatase HemH; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.757 |
| hemB | hemN | SO_2587 | SO_4730 | Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family. | Coproporphyrinogen III oxidase oxygen-independent HemN; Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.783 |