Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
yrfGHAD-superfamily hydrolase subfamily IA variant 3 protein family YrfG. (220 aa)    
Predicted Functional Partners:
guaB
Inosine-5-monophosphate dehydrogenase GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 0.920
ppnP
Protein of unknown function DUF1255; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.
  
 
  0.918
guaA
GMP synthase (glutamine-hydrolysing) GuaA; Catalyzes the synthesis of GMP from XMP.
  
 
 0.914
surE
5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.913
nagD
Haloacid dehalogenase subfamily IIA associated with N-acetylglucosamine degradation NagD.
   
 
 0.908
gmk
Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP.
     
  0.906
purH
Bifunctional IMP cyclohydrolase/phosphoribosylaminoimidazolecarboxamide formyltransferase PurH.
    
  0.902
ushA
Bifunctional UDP-sugar hydrolase/5'-nucleotidase UshA; Belongs to the 5'-nucleotidase family.
   
 
 0.902
SO_3317
5'-nucleotidase; Belongs to the 5'-nucleotidase family.
   
 
 0.902
cpdB
Bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3`-nucleotidase CpdB; Belongs to the 5'-nucleotidase family.
   
 
 0.902
Your Current Organism:
Shewanella oneidensis
NCBI taxonomy Id: 211586
Other names: S. oneidensis MR-1, Shewanella oneidensis ATCC 700550, Shewanella oneidensis MR-1, Shewanella oneidensis str. MR-1, Shewanella oneidensis strain MR-1, Shewanella sp. MR-1
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