| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| bkdA1 | bkdA2 | SO_2339 | SO_2340 | 3-methyl-2-oxobutanoate dehydrogenase complex E1 component alpha subunit BkdA1. | 3-methyl-2-oxobutanoate dehydrogenase complex E1 component beta subunit BkdA2. | 0.999 |
| bkdA1 | ilvA | SO_2339 | SO_4344 | 3-methyl-2-oxobutanoate dehydrogenase complex E1 component alpha subunit BkdA1. | Threonine dehydratase IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.815 |
| bkdA1 | ilvE | SO_2339 | SO_0340 | 3-methyl-2-oxobutanoate dehydrogenase complex E1 component alpha subunit BkdA1. | Branched-chain-amino-acid transaminase IlvE. | 0.924 |
| bkdA1 | ldh | SO_2339 | SO_2638 | 3-methyl-2-oxobutanoate dehydrogenase complex E1 component alpha subunit BkdA1. | Leucine dehydrogenase Ldh. | 0.972 |
| bkdA2 | bkdA1 | SO_2340 | SO_2339 | 3-methyl-2-oxobutanoate dehydrogenase complex E1 component beta subunit BkdA2. | 3-methyl-2-oxobutanoate dehydrogenase complex E1 component alpha subunit BkdA1. | 0.999 |
| bkdA2 | ilvA | SO_2340 | SO_4344 | 3-methyl-2-oxobutanoate dehydrogenase complex E1 component beta subunit BkdA2. | Threonine dehydratase IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.821 |
| bkdA2 | ilvE | SO_2340 | SO_0340 | 3-methyl-2-oxobutanoate dehydrogenase complex E1 component beta subunit BkdA2. | Branched-chain-amino-acid transaminase IlvE. | 0.927 |
| bkdA2 | ldh | SO_2340 | SO_2638 | 3-methyl-2-oxobutanoate dehydrogenase complex E1 component beta subunit BkdA2. | Leucine dehydrogenase Ldh. | 0.962 |
| bkdA2 | metL | SO_2340 | SO_4055 | 3-methyl-2-oxobutanoate dehydrogenase complex E1 component beta subunit BkdA2. | Bifunctional aspartokinase II/homoserine dehydrogenase methionine-sensitive MetL; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.405 |
| bkdA2 | thrA | SO_2340 | SO_3415 | 3-methyl-2-oxobutanoate dehydrogenase complex E1 component beta subunit BkdA2. | Bifunctional aspartokinase I / homoserine dehydrogenase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.405 |
| ilvA | bkdA1 | SO_4344 | SO_2339 | Threonine dehydratase IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 3-methyl-2-oxobutanoate dehydrogenase complex E1 component alpha subunit BkdA1. | 0.815 |
| ilvA | bkdA2 | SO_4344 | SO_2340 | Threonine dehydratase IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 3-methyl-2-oxobutanoate dehydrogenase complex E1 component beta subunit BkdA2. | 0.821 |
| ilvA | ilvD | SO_4344 | SO_4345 | Threonine dehydratase IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Dihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. | 0.991 |
| ilvA | ilvE | SO_4344 | SO_0340 | Threonine dehydratase IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Branched-chain-amino-acid transaminase IlvE. | 0.953 |
| ilvA | leuA | SO_4344 | SO_4236 | Threonine dehydratase IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 2-isopropylmalate synthase LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.548 |
| ilvA | metL | SO_4344 | SO_4055 | Threonine dehydratase IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Bifunctional aspartokinase II/homoserine dehydrogenase methionine-sensitive MetL; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.659 |
| ilvA | thrA | SO_4344 | SO_3415 | Threonine dehydratase IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Bifunctional aspartokinase I / homoserine dehydrogenase I ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.659 |
| ilvD | ilvA | SO_4345 | SO_4344 | Dihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. | Threonine dehydratase IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.991 |
| ilvD | ilvE | SO_4345 | SO_0340 | Dihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. | Branched-chain-amino-acid transaminase IlvE. | 0.992 |
| ilvD | ldh | SO_4345 | SO_2638 | Dihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. | Leucine dehydrogenase Ldh. | 0.913 |
