| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| apt | gmk | SO_2012 | SO_0361 | Adenine phosphoribosyltransferase Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. | 0.973 |
| apt | gsk | SO_2012 | SO_2020 | Adenine phosphoribosyltransferase Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-guanosine kinase Gsk. | 0.950 |
| apt | guaA | SO_2012 | SO_3292 | Adenine phosphoribosyltransferase Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolysing) GuaA; Catalyzes the synthesis of GMP from XMP. | 0.998 |
| apt | hprT | SO_2012 | SO_3803 | Adenine phosphoribosyltransferase Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Hypoxanthine phosphoribosyltransferase HprT; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.943 |
| apt | ndk | SO_2012 | SO_2274 | Adenine phosphoribosyltransferase Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Nucleoside diphosphate kinase Ndk; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.460 |
| gmk | apt | SO_0361 | SO_2012 | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.973 |
| gmk | gsk | SO_0361 | SO_2020 | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. | Inosine-guanosine kinase Gsk. | 0.916 |
| gmk | guaA | SO_0361 | SO_3292 | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. | GMP synthase (glutamine-hydrolysing) GuaA; Catalyzes the synthesis of GMP from XMP. | 0.968 |
| gmk | hprT | SO_0361 | SO_3803 | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. | Hypoxanthine phosphoribosyltransferase HprT; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.946 |
| gmk | ndk | SO_0361 | SO_2274 | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. | Nucleoside diphosphate kinase Ndk; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.948 |
| gmk | nrdA | SO_0361 | SO_2415 | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. | Aerobic ribonucleoside-diphosphate reductase alpha subunit NrdA; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.916 |
| gmk | prsA | SO_0361 | SO_3837 | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. | Ribose-phosphate pyrophosphokinase PrsA; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.942 |
| gmk | pykA | SO_0361 | SO_2491 | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. | Pyruvate kinase II PykA; Belongs to the pyruvate kinase family. | 0.922 |
| gmk | rpoZ | SO_0361 | SO_0360 | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. | DNA-directed RNA polymerase omega subunit RpoZ; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.981 |
| gmk | spoT | SO_0361 | SO_0359 | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. | Bifunctional ppGpp phosphohydrolase/GTP diphosphokinase SpoT; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.961 |
| gsk | apt | SO_2020 | SO_2012 | Inosine-guanosine kinase Gsk. | Adenine phosphoribosyltransferase Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.950 |
| gsk | gmk | SO_2020 | SO_0361 | Inosine-guanosine kinase Gsk. | Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. | 0.916 |
| gsk | guaA | SO_2020 | SO_3292 | Inosine-guanosine kinase Gsk. | GMP synthase (glutamine-hydrolysing) GuaA; Catalyzes the synthesis of GMP from XMP. | 0.940 |
| gsk | hprT | SO_2020 | SO_3803 | Inosine-guanosine kinase Gsk. | Hypoxanthine phosphoribosyltransferase HprT; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.911 |
| guaA | apt | SO_3292 | SO_2012 | GMP synthase (glutamine-hydrolysing) GuaA; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase Apt; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.998 |