STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SO_0381Type I RM locus Fic family protein. (332 aa)    
Predicted Functional Partners:
hsdS
Type I restriction-modification system restriction endonuclease DNA specificity subunit HsdS.
 
    0.869
hsdM
Type I restriction-modification system N6-adenine DNA methyltransferase HsdM.
 
    0.852
hsdR
Type I restriction-modification system restriction endonuclease cleavage subunit HsdR; Subunit R is required for both nuclease and ATPase activities, but not for modification.
 
    0.851
ligA
DNA ligase NAD-dependent LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
      0.743
hsdM-2
Type I restriction-modification system N6-adenine DNA methyltransferase HsdM.
 
    0.697
SO_1457
Type II restriction-modification system methyltransferase.
 
    0.676
hsdS-3
Type I restriction-modification system restriction endonuclease DNA specificity subunit HsdS.
  
    0.670
SO_0379
Protein of unknown function DUF45.
  
    0.516
hipA
Toxin-antitoxin system toxin HipA family; Toxic component of a type II toxin-antitoxin (TA) system; overexpression in wild-type temporarily inhibits cell growth, overexpression in a hipAB deletion leads to acute growth inhibition. The toxic effect of HipA is neutralized by its cognate antitoxin HipB. In the ternary phosphoserine-HipA-HipB-DNA complex the DNA is bent about 125 degrees; all HipA in the crystallized ternary complex is phosphorylated. In E.coli phosphorylation of HipA is thought to release HipB from the HipA-HipB-DNA complex, suggesting the complex functions differently in [...]
  
   
 0.491
SO_0063
Toxin-antitoxin system toxin HipA family.
  
   
 0.486
Your Current Organism:
Shewanella oneidensis
NCBI taxonomy Id: 211586
Other names: S. oneidensis MR-1, Shewanella oneidensis ATCC 700550, Shewanella oneidensis MR-1, Shewanella oneidensis str. MR-1, Shewanella oneidensis strain MR-1, Shewanella sp. MR-1
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