| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SO_0497 | sirB | SO_0497 | SO_0480 | Serine/threonine protein kinase. | Sulfurtransferase SirB. | 0.687 |
| SO_0497 | sirG | SO_0497 | SO_0482 | Serine/threonine protein kinase. | Cytochrome c maturation system haem lyase subunit SirG. | 0.410 |
| SO_3700 | sirB | SO_3700 | SO_0480 | Bifunctional periplasmic substrate binding protein/cytoplasmic diguanylate cyclase. | Sulfurtransferase SirB. | 0.701 |
| rfbc | rffG | SO_3160 | SO_3167 | dTDP-4-keto-L-rhamnose-35-epimerase RfbC; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. | dTDP-glucose-4,6-dehydratase RffG; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. | 0.999 |
| rfbc | rsmB | SO_3160 | SO_0030 | dTDP-4-keto-L-rhamnose-35-epimerase RfbC; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. | 16S rRNA (cytosine967-C5)-methyltransferase RsmB; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.450 |
| rfbc | sirB | SO_3160 | SO_0480 | dTDP-4-keto-L-rhamnose-35-epimerase RfbC; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. | Sulfurtransferase SirB. | 0.782 |
| rffG | rfbc | SO_3167 | SO_3160 | dTDP-glucose-4,6-dehydratase RffG; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. | dTDP-4-keto-L-rhamnose-35-epimerase RfbC; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. | 0.999 |
| rffG | rsmB | SO_3167 | SO_0030 | dTDP-glucose-4,6-dehydratase RffG; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. | 16S rRNA (cytosine967-C5)-methyltransferase RsmB; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.759 |
| rffG | rsmB-2 | SO_3167 | SO_1575 | dTDP-glucose-4,6-dehydratase RffG; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. | tRNA/rRNA cytosine-C5-methylase RsmB; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | 0.729 |
| rffG | sirB | SO_3167 | SO_0480 | dTDP-glucose-4,6-dehydratase RffG; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. | Sulfurtransferase SirB. | 0.920 |
| rsmB | rfbc | SO_0030 | SO_3160 | 16S rRNA (cytosine967-C5)-methyltransferase RsmB; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | dTDP-4-keto-L-rhamnose-35-epimerase RfbC; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. | 0.450 |
| rsmB | rffG | SO_0030 | SO_3167 | 16S rRNA (cytosine967-C5)-methyltransferase RsmB; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | dTDP-glucose-4,6-dehydratase RffG; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. | 0.759 |
| rsmB | sirB | SO_0030 | SO_0480 | 16S rRNA (cytosine967-C5)-methyltransferase RsmB; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Sulfurtransferase SirB. | 0.734 |
| rsmB-2 | rffG | SO_1575 | SO_3167 | tRNA/rRNA cytosine-C5-methylase RsmB; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | dTDP-glucose-4,6-dehydratase RffG; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. | 0.729 |
| rsmB-2 | sirB | SO_1575 | SO_0480 | tRNA/rRNA cytosine-C5-methylase RsmB; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. | Sulfurtransferase SirB. | 0.734 |
| sirA | sirB | SO_0479 | SO_0480 | Sulfite reductase octaheme cytochrome c SirA; Respiratory sulfite reductase that catalyzes the reduction of sulfite to sulfide in a single step, consuming six electrons in the process. Required for sulfite respiration under anaerobic growth conditions. Does not contribute to nitrite reduction. | Sulfurtransferase SirB. | 0.741 |
| sirA | sirD | SO_0479 | SO_0484 | Sulfite reductase octaheme cytochrome c SirA; Respiratory sulfite reductase that catalyzes the reduction of sulfite to sulfide in a single step, consuming six electrons in the process. Required for sulfite respiration under anaerobic growth conditions. Does not contribute to nitrite reduction. | Menaquinol oxidase SirD. | 0.782 |
| sirA | sirG | SO_0479 | SO_0482 | Sulfite reductase octaheme cytochrome c SirA; Respiratory sulfite reductase that catalyzes the reduction of sulfite to sulfide in a single step, consuming six electrons in the process. Required for sulfite respiration under anaerobic growth conditions. Does not contribute to nitrite reduction. | Cytochrome c maturation system haem lyase subunit SirG. | 0.661 |
| sirA | sirI | SO_0479 | SO_0481 | Sulfite reductase octaheme cytochrome c SirA; Respiratory sulfite reductase that catalyzes the reduction of sulfite to sulfide in a single step, consuming six electrons in the process. Required for sulfite respiration under anaerobic growth conditions. Does not contribute to nitrite reduction. | Cytochrome c maturation system peptidyl-prolyl cis-trans isomerase SirI. | 0.945 |
| sirB | SO_0497 | SO_0480 | SO_0497 | Sulfurtransferase SirB. | Serine/threonine protein kinase. | 0.687 |