| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SO_0544 | SO_0545 | SO_0544 | SO_0545 | Two component signal transduction system histidine kinase with CHASE and PAS sensory domains. | Two component signal transduction system response regulator with diguanylate cyclase/phosphodiesterase acitivity. | 0.925 |
| SO_0544 | SO_0859 | SO_0544 | SO_0859 | Two component signal transduction system histidine kinase with CHASE and PAS sensory domains. | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | 0.952 |
| SO_0544 | SO_2544 | SO_0544 | SO_2544 | Two component signal transduction system histidine kinase with CHASE and PAS sensory domains. | Two component signal transduction system hybrid histidine kinase/response regulator with Hpt domain. | 0.940 |
| SO_0544 | SO_3759 | SO_0544 | SO_3759 | Two component signal transduction system histidine kinase with CHASE and PAS sensory domains. | Diguanylate cyclase with GAF sensory domain. | 0.934 |
| SO_0544 | SO_4002 | SO_0544 | SO_4002 | Two component signal transduction system histidine kinase with CHASE and PAS sensory domains. | Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | 0.954 |
| SO_0544 | SO_4445 | SO_0544 | SO_4445 | Two component signal transduction system histidine kinase with CHASE and PAS sensory domains. | Two component signal transduction system hybrid histidine kinase/response regulator. | 0.949 |
| SO_0544 | SO_4768 | SO_0544 | SO_4768 | Two component signal transduction system histidine kinase with CHASE and PAS sensory domains. | Two component signal transduction system response regulator. | 0.952 |
| SO_0544 | barA | SO_0544 | SO_3457 | Two component signal transduction system histidine kinase with CHASE and PAS sensory domains. | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with DUF2222 and Hpt domains BarA. | 0.963 |
| SO_0544 | prlS | SO_0544 | SO_2742 | Two component signal transduction system histidine kinase with CHASE and PAS sensory domains. | Proline-responsive two component signal transduction system hybrid histidine kinase/resposne regulator PrlS. | 0.911 |
| SO_0544 | torS | SO_0544 | SO_1230 | Two component signal transduction system histidine kinase with CHASE and PAS sensory domains. | Histidine kinase; TMAO-responsive two component signal transduction system hybrid histidine kinase/response regulator TorS. | 0.940 |
| SO_0545 | SO_0544 | SO_0545 | SO_0544 | Two component signal transduction system response regulator with diguanylate cyclase/phosphodiesterase acitivity. | Two component signal transduction system histidine kinase with CHASE and PAS sensory domains. | 0.925 |
| SO_0545 | SO_0859 | SO_0545 | SO_0859 | Two component signal transduction system response regulator with diguanylate cyclase/phosphodiesterase acitivity. | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | 0.970 |
| SO_0545 | SO_2544 | SO_0545 | SO_2544 | Two component signal transduction system response regulator with diguanylate cyclase/phosphodiesterase acitivity. | Two component signal transduction system hybrid histidine kinase/response regulator with Hpt domain. | 0.716 |
| SO_0545 | SO_3759 | SO_0545 | SO_3759 | Two component signal transduction system response regulator with diguanylate cyclase/phosphodiesterase acitivity. | Diguanylate cyclase with GAF sensory domain. | 0.616 |
| SO_0545 | SO_4002 | SO_0545 | SO_4002 | Two component signal transduction system response regulator with diguanylate cyclase/phosphodiesterase acitivity. | Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | 0.956 |
| SO_0545 | SO_4445 | SO_0545 | SO_4445 | Two component signal transduction system response regulator with diguanylate cyclase/phosphodiesterase acitivity. | Two component signal transduction system hybrid histidine kinase/response regulator. | 0.820 |
| SO_0545 | SO_4768 | SO_0545 | SO_4768 | Two component signal transduction system response regulator with diguanylate cyclase/phosphodiesterase acitivity. | Two component signal transduction system response regulator. | 0.796 |
| SO_0545 | barA | SO_0545 | SO_3457 | Two component signal transduction system response regulator with diguanylate cyclase/phosphodiesterase acitivity. | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with DUF2222 and Hpt domains BarA. | 0.979 |
| SO_0545 | prlS | SO_0545 | SO_2742 | Two component signal transduction system response regulator with diguanylate cyclase/phosphodiesterase acitivity. | Proline-responsive two component signal transduction system hybrid histidine kinase/resposne regulator PrlS. | 0.653 |
| SO_0545 | torS | SO_0545 | SO_1230 | Two component signal transduction system response regulator with diguanylate cyclase/phosphodiesterase acitivity. | Histidine kinase; TMAO-responsive two component signal transduction system hybrid histidine kinase/response regulator TorS. | 0.893 |