| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| birA | eno | SO_0214 | SO_3440 | Bifunctional biotin operon repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Enolase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | 0.591 |
| birA | galM | SO_0214 | SO_0693 | Bifunctional biotin operon repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Aldose 1-epimerase GalM; Converts alpha-aldose to the beta-anomer. | 0.812 |
| birA | glgB | SO_0214 | SO_1494 | Bifunctional biotin operon repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 1,4-alpha-glucan branching enzyme GlgB; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. | 0.714 |
| birA | sixA | SO_0214 | SO_3082 | Bifunctional biotin operon repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Phosphohistidine phosphatase SixA; Belongs to the phosphoglycerate mutase family. | 0.768 |
| birA | tkt | SO_0214 | SO_0930 | Bifunctional biotin operon repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Transketolase Tkt; Belongs to the transketolase family. | 0.614 |
| cga | galE | SO_2459 | SO_1664 | Glucan 14-alpha-glucosidase Cga. | UDP-glucose 4-epimerase GalE; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | 0.510 |
| cga | galK | SO_2459 | SO_0694 | Glucan 14-alpha-glucosidase Cga. | Galactokinase GalK; Belongs to the GHMP kinase family. GalK subfamily. | 0.521 |
| cga | galM | SO_2459 | SO_0693 | Glucan 14-alpha-glucosidase Cga. | Aldose 1-epimerase GalM; Converts alpha-aldose to the beta-anomer. | 0.590 |
| cga | glgB | SO_2459 | SO_1494 | Glucan 14-alpha-glucosidase Cga. | 1,4-alpha-glucan branching enzyme GlgB; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. | 0.933 |
| cga | nagA | SO_2459 | SO_3505 | Glucan 14-alpha-glucosidase Cga. | N-acetylglucosamine-6-phosphate deacetylase NagA; Belongs to the metallo-dependent hydrolases superfamily. NagA family. | 0.591 |
| eno | birA | SO_3440 | SO_0214 | Enolase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | Bifunctional biotin operon repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.591 |
| eno | galM | SO_3440 | SO_0693 | Enolase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | Aldose 1-epimerase GalM; Converts alpha-aldose to the beta-anomer. | 0.802 |
| eno | galU | SO_3440 | SO_1665 | Enolase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | UTP-glucose-1-phosphate uridylyltransferase GalU. | 0.502 |
| eno | glgB | SO_3440 | SO_1494 | Enolase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | 1,4-alpha-glucan branching enzyme GlgB; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. | 0.836 |
| eno | sixA | SO_3440 | SO_3082 | Enolase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | Phosphohistidine phosphatase SixA; Belongs to the phosphoglycerate mutase family. | 0.749 |
| eno | tkt | SO_3440 | SO_0930 | Enolase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. | Transketolase Tkt; Belongs to the transketolase family. | 0.976 |
| galE | cga | SO_1664 | SO_2459 | UDP-glucose 4-epimerase GalE; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | Glucan 14-alpha-glucosidase Cga. | 0.510 |
| galE | galK | SO_1664 | SO_0694 | UDP-glucose 4-epimerase GalE; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | Galactokinase GalK; Belongs to the GHMP kinase family. GalK subfamily. | 0.997 |
| galE | galM | SO_1664 | SO_0693 | UDP-glucose 4-epimerase GalE; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | Aldose 1-epimerase GalM; Converts alpha-aldose to the beta-anomer. | 0.986 |
| galE | galU | SO_1664 | SO_1665 | UDP-glucose 4-epimerase GalE; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | UTP-glucose-1-phosphate uridylyltransferase GalU. | 0.997 |