Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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mdhNAD dependent malate dehydrogenase Mdh; Catalyzes the reversible oxidation of malate to oxaloacetate. (311 aa)    
Predicted Functional Partners:
prpC
2-methylcitrate synthase PrpC; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and via the 2-methylcitrate cycle II (propionate degradation route). Catalyzes the Claisen condensation of propionyl-CoA and oxaloacetate (OAA) to yield 2-methylcitrate (2-MC) and CoA. Catalyzes the condensation of oxaloacetate with acetyl-CoA (By similarity).
  
 0.997
gltA
Citrate synthase GltA; Belongs to the citrate synthase family.
  
 0.996
fumB
Anaerobic fumarate hydratase FumB; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.996
sfcA
NAD-dependent malate dehydrogenase (oxaloacetate-decarboxylating) SfcA; Belongs to the malic enzymes family.
  
 0.954
maeB
NADP-dependent malate dehydrogenase (oxaloacetate-decarboxylating) MaeB.
  
 0.954
aspC-2
Aspartate aminotransferase AspC.
   
 0.948
ppc
Phosphoenolpyruvate carboxylase Ppc; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
     
 0.947
icd
Isocitrate dehydrogenase NADP-dependent Icd; Belongs to the monomeric-type IDH family.
  
  
 0.934
acnB
Aconitate hydratase AcnB; Belongs to the aconitase/IPM isomerase family.
  
  
 0.933
pckA
Phosphoenolpyruvate carboxykinase PckA; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
  
 
 0.932
Your Current Organism:
Shewanella oneidensis
NCBI taxonomy Id: 211586
Other names: S. oneidensis MR-1, Shewanella oneidensis ATCC 700550, Shewanella oneidensis MR-1, Shewanella oneidensis str. MR-1, Shewanella oneidensis strain MR-1, Shewanella sp. MR-1
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