Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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metRTranscription regulator of methionine biosynthesis MetR; Belongs to the LysR transcriptional regulatory family. (301 aa)    
Predicted Functional Partners:
metE
B12-independent 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
 
   
 0.948
hmgR
Homogentisate-responsive transcriptional repressor of homogenetisate degradation HmgR; Belongs to the LysR transcriptional regulatory family.
  
   
 0.867
metJ
Transcriptional repressor of methionine metabolism MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family.
   
  
 0.810
SO_4524
Transcriptional regulator LysR family; Belongs to the LysR transcriptional regulatory family.
  
     0.674
SO_1259
Transcriptional regulator LysR family; Belongs to the LysR transcriptional regulatory family.
  
     0.669
glyA
Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
      
 0.664
SO_0523
Transcriptional regulator LysR family; Belongs to the LysR transcriptional regulatory family.
  
     0.652
SO_0701
Transcriptional regulator LysR family; Belongs to the LysR transcriptional regulatory family.
  
    0.648
lldR
Transcriptional regulator of L-lactate utilization LldR; Belongs to the LysR transcriptional regulatory family.
  
     0.603
SO_2438
Transcriptional regulator LysR family; Belongs to the LysR transcriptional regulatory family.
  
    0.602
Your Current Organism:
Shewanella oneidensis
NCBI taxonomy Id: 211586
Other names: S. oneidensis MR-1, Shewanella oneidensis ATCC 700550, Shewanella oneidensis MR-1, Shewanella oneidensis str. MR-1, Shewanella oneidensis strain MR-1, Shewanella sp. MR-1
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