Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
macBABC-type macrolide export system bifunctional ATPase and permease component MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (656 aa)    
Predicted Functional Partners:
macA
ABC-type macrolide export systemMFP component MacA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 0.999
macC
ABC-type macrolide export system secretin component MacC.
 0.998
vmeA
Proton-coupled multidrug efflux pump MFP component VmeA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.857
tolC
Global secretion system secretin TolC.
  
 
 0.848
mexE
HAE1 family efflux pump MFP component MexE; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.842
SO_1881
HAE1 family efflux pump MFP component; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.841
vexB
RND-type multidrug/detergent efflux system MFP component VexB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.840
SO_4015
HAE1 family effllux pump MFP component; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.833
SO_0923
Lipoprotein of unknown function DUF306.
    
   0.824
oleC
Polyolefin biosynthetic pathway AMP transfer protein OleC; Involved in olefin biosynthesis. Catalyzes the conversion of 2-alkyl-3-hydroxyalkanoic acids to beta-lactones in the presence of ATP (By similarity). The S.oneidensis oleABCD genes produce 3,6,9,12,15,19,22,25,28-hentriacontanonaene, which may aid the cells in adapting to a sudden drop in temperature.
  
  
 0.814
Your Current Organism:
Shewanella oneidensis
NCBI taxonomy Id: 211586
Other names: S. oneidensis MR-1, Shewanella oneidensis ATCC 700550, Shewanella oneidensis MR-1, Shewanella oneidensis str. MR-1, Shewanella oneidensis strain MR-1, Shewanella sp. MR-1
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