| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SO_4376 | rsmE | SO_4376 | SO_0832 | Uncharacterized protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). | 16S rRNA (uracil1498-N3)-methyltransferase RsmE; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.865 |
| csrA | glgC | SO_3426 | SO_1498 | Carbon storage regulator CsrA; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). | Glucose-1-phosphate adenylyltransferase GlgC; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. | 0.782 |
| csrA | rne | SO_3426 | SO_2785 | Carbon storage regulator CsrA; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). | Ribonuclease E Rne; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. | 0.759 |
| csrA | rsmE | SO_3426 | SO_0832 | Carbon storage regulator CsrA; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). | 16S rRNA (uracil1498-N3)-methyltransferase RsmE; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.779 |
| csrA | rsmF | SO_3426 | SO_2609 | Carbon storage regulator CsrA; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). | 16S rRNA (cytosine1407-C5)-methyltransferase RsmF; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. | 0.815 |
| endA | gshB | SO_0833 | SO_0831 | Endonuclease I EndA. | ATP-dependent glutathione synthetase GshB. | 0.572 |
| endA | rsmE | SO_0833 | SO_0832 | Endonuclease I EndA. | 16S rRNA (uracil1498-N3)-methyltransferase RsmE; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.919 |
| endA | rsmF | SO_0833 | SO_2609 | Endonuclease I EndA. | 16S rRNA (cytosine1407-C5)-methyltransferase RsmF; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. | 0.422 |
| endA | sprT | SO_0833 | SO_0834 | Endonuclease I EndA. | Protein of unknown function DUF335 SprT; Belongs to the SprT family. | 0.590 |
| glgC | csrA | SO_1498 | SO_3426 | Glucose-1-phosphate adenylyltransferase GlgC; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. | Carbon storage regulator CsrA; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). | 0.782 |
| glgC | rsmE | SO_1498 | SO_0832 | Glucose-1-phosphate adenylyltransferase GlgC; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. | 16S rRNA (uracil1498-N3)-methyltransferase RsmE; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.775 |
| gshB | endA | SO_0831 | SO_0833 | ATP-dependent glutathione synthetase GshB. | Endonuclease I EndA. | 0.572 |
| gshB | rsmE | SO_0831 | SO_0832 | ATP-dependent glutathione synthetase GshB. | 16S rRNA (uracil1498-N3)-methyltransferase RsmE; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.646 |
| gshB | sprT | SO_0831 | SO_0834 | ATP-dependent glutathione synthetase GshB. | Protein of unknown function DUF335 SprT; Belongs to the SprT family. | 0.405 |
| prmA | rsmE | SO_0395 | SO_0832 | Ribosomal protein L11 methyltransferase PrmA; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. | 16S rRNA (uracil1498-N3)-methyltransferase RsmE; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.853 |
| prmA | rsmF | SO_0395 | SO_2609 | Ribosomal protein L11 methyltransferase PrmA; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. | 16S rRNA (cytosine1407-C5)-methyltransferase RsmF; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. | 0.559 |
| prmA | rsmG | SO_0395 | SO_4757 | Ribosomal protein L11 methyltransferase PrmA; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. | 16S rRNA (guanine527-N7)-methyltransferase RsmG; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. | 0.566 |
| rne | csrA | SO_2785 | SO_3426 | Ribonuclease E Rne; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. | Carbon storage regulator CsrA; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). | 0.759 |
| rne | rsmE | SO_2785 | SO_0832 | Ribonuclease E Rne; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. | 16S rRNA (uracil1498-N3)-methyltransferase RsmE; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | 0.606 |
| rsmE | SO_4376 | SO_0832 | SO_4376 | 16S rRNA (uracil1498-N3)-methyltransferase RsmE; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. | Uncharacterized protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). | 0.865 |