Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nhaRTranscriptional activator of osmotic stress protection NhaR; Belongs to the LysR transcriptional regulatory family. (302 aa)    
Predicted Functional Partners:
nhaA
Na+/H+ antiporter NhaA; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
  
  
 0.946
sdhE
Protein of unknown function DUF339; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
  
    0.562
SO_1337
Predicted periplasmic protein.
  
    0.553
ilvY
LysR family transcriptional regulator, positive regulator for ilvC; Acetohydroxybutyrate/acetolactate-responsive transcriptional regulator of isoleucine-valine biosynthesis IlvY; Belongs to the LysR transcriptional regulatory family.
  
  
 0.499
cyaA
Adenylate cyclase CyaA; Belongs to the adenylyl cyclase class-1 family.
  
  
 0.481
SO_1340
Protein of unknown function DUF1434.
  
    0.468
sdaR
Transcriptional repressor of glycerate utilization SdaR.
  
   
 0.459
csrA
Carbon storage regulator CsrA; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
     
 0.452
phoU
Transcriptional regulator of high affinity phosphate uptake system PhoU; Plays a role in the regulation of phosphate uptake.
   
  
 0.441
SO_2251
Enzyme of unknown function UPF0227; Belongs to the UPF0227 family.
  
     0.426
Your Current Organism:
Shewanella oneidensis
NCBI taxonomy Id: 211586
Other names: S. oneidensis MR-1, Shewanella oneidensis ATCC 700550, Shewanella oneidensis MR-1, Shewanella oneidensis str. MR-1, Shewanella oneidensis strain MR-1, Shewanella sp. MR-1
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