STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hypANiFe hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (118 aa)    
Predicted Functional Partners:
hypF
NiFe hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.991
hypB
Ni2+-binding GTPase involved in regulation of NiFe hydrogenase expression and maturation HypB.
 
 
 0.984
hyaB
Periplasmic [Ni-Fe] hydrogenase large subunit HyaB; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.984
hypE
NiFe hydrogenase accessory/formation protein HypE.
 
  
 0.973
hypD
NiFe hydrogenase expression/formation protein HypD; Belongs to the HypD family.
 
  
 0.972
hyaA
Periplasmic [Ni-Fe] hydrogenase small subunit HyaA.
 
  
 0.971
hypC
NiFe hydrogenase assembly chaperone HypC.
 
  
 0.945
hyaD
NiFe hydrogenase maturation protease HyaD.
 
  
 0.895
hyaC
Periplasmic [Ni-Fe] hydrogenase cytochrome b subunit HyaC.
 
   
 0.858
apbC
Scaffold protein for [4Fe-4S] cluster assembly ApbC; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
   
   0.823
Your Current Organism:
Shewanella oneidensis
NCBI taxonomy Id: 211586
Other names: S. oneidensis MR-1, Shewanella oneidensis ATCC 700550, Shewanella oneidensis MR-1, Shewanella oneidensis str. MR-1, Shewanella oneidensis strain MR-1, Shewanella sp. MR-1
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