| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SO_0859 | SO_2127 | SO_0859 | SO_2127 | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | Diguanylate cyclase with response regulator receiver modulation. | 0.989 |
| SO_0859 | SO_2544 | SO_0859 | SO_2544 | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | Two component signal transduction system hybrid histidine kinase/response regulator with Hpt domain. | 0.984 |
| SO_0859 | SO_2889 | SO_0859 | SO_2889 | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | Two component signal transduction system histidine kinase with Cache_1 and PAS sensory domains. | 0.981 |
| SO_0859 | SO_3162 | SO_0859 | SO_3162 | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | Two component signal transduction system histidine kinase with GAF sensory domain. | 0.962 |
| SO_0859 | SO_4002 | SO_0859 | SO_4002 | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | 0.991 |
| SO_0859 | SO_4445 | SO_0859 | SO_4445 | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | Two component signal transduction system hybrid histidine kinase/response regulator. | 0.984 |
| SO_0859 | SO_4734 | SO_0859 | SO_4734 | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | Bifunctional diguanylate cyclase/phosphodiesterase with PAS sensory domain. | 0.987 |
| SO_0859 | barA | SO_0859 | SO_3457 | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with DUF2222 and Hpt domains BarA. | 0.991 |
| SO_0859 | prlS | SO_0859 | SO_2742 | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | Proline-responsive two component signal transduction system hybrid histidine kinase/resposne regulator PrlS. | 0.986 |
| SO_0859 | torS | SO_0859 | SO_1230 | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | Histidine kinase; TMAO-responsive two component signal transduction system hybrid histidine kinase/response regulator TorS. | 0.989 |
| SO_2127 | SO_0859 | SO_2127 | SO_0859 | Diguanylate cyclase with response regulator receiver modulation. | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | 0.989 |
| SO_2127 | SO_2544 | SO_2127 | SO_2544 | Diguanylate cyclase with response regulator receiver modulation. | Two component signal transduction system hybrid histidine kinase/response regulator with Hpt domain. | 0.986 |
| SO_2127 | SO_2889 | SO_2127 | SO_2889 | Diguanylate cyclase with response regulator receiver modulation. | Two component signal transduction system histidine kinase with Cache_1 and PAS sensory domains. | 0.973 |
| SO_2127 | SO_3162 | SO_2127 | SO_3162 | Diguanylate cyclase with response regulator receiver modulation. | Two component signal transduction system histidine kinase with GAF sensory domain. | 0.950 |
| SO_2127 | SO_4002 | SO_2127 | SO_4002 | Diguanylate cyclase with response regulator receiver modulation. | Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain. | 0.992 |
| SO_2127 | SO_4445 | SO_2127 | SO_4445 | Diguanylate cyclase with response regulator receiver modulation. | Two component signal transduction system hybrid histidine kinase/response regulator. | 0.986 |
| SO_2127 | SO_4734 | SO_2127 | SO_4734 | Diguanylate cyclase with response regulator receiver modulation. | Bifunctional diguanylate cyclase/phosphodiesterase with PAS sensory domain. | 0.951 |
| SO_2127 | barA | SO_2127 | SO_3457 | Diguanylate cyclase with response regulator receiver modulation. | Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with DUF2222 and Hpt domains BarA. | 0.992 |
| SO_2127 | prlS | SO_2127 | SO_2742 | Diguanylate cyclase with response regulator receiver modulation. | Proline-responsive two component signal transduction system hybrid histidine kinase/resposne regulator PrlS. | 0.982 |
| SO_2127 | torS | SO_2127 | SO_1230 | Diguanylate cyclase with response regulator receiver modulation. | Histidine kinase; TMAO-responsive two component signal transduction system hybrid histidine kinase/response regulator TorS. | 0.989 |