| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SO_2180 | queD | SO_2180 | SO_2179 | Periplasmic metalloprotease M23B family. | Queosine biosynthesis protein QueD. | 0.619 |
| SO_2535 | folE | SO_2535 | SO_4254 | Glutamine amidotransferase class II. | GTP cyclohydrolase I FolE. | 0.970 |
| SO_2535 | queC | SO_2535 | SO_2503 | Glutamine amidotransferase class II. | Queuosine biosynthesis ATPase QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.971 |
| SO_2535 | queD | SO_2535 | SO_2179 | Glutamine amidotransferase class II. | Queosine biosynthesis protein QueD. | 0.970 |
| cysS | hisIE | SO_1791 | SO_2067 | cysteinyl-tRNA synthetase CysS; Belongs to the class-I aminoacyl-tRNA synthetase family. | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase HisIE; In the C-terminal section; belongs to the PRA-PH family. | 0.679 |
| cysS | queD | SO_1791 | SO_2179 | cysteinyl-tRNA synthetase CysS; Belongs to the class-I aminoacyl-tRNA synthetase family. | Queosine biosynthesis protein QueD. | 0.602 |
| folE | SO_2535 | SO_4254 | SO_2535 | GTP cyclohydrolase I FolE. | Glutamine amidotransferase class II. | 0.970 |
| folE | hisIE | SO_4254 | SO_2067 | GTP cyclohydrolase I FolE. | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase HisIE; In the C-terminal section; belongs to the PRA-PH family. | 0.546 |
| folE | queC | SO_4254 | SO_2503 | GTP cyclohydrolase I FolE. | Queuosine biosynthesis ATPase QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.982 |
| folE | queD | SO_4254 | SO_2179 | GTP cyclohydrolase I FolE. | Queosine biosynthesis protein QueD. | 0.988 |
| folE | queE | SO_4254 | SO_2501 | GTP cyclohydrolase I FolE. | Queuosine biosynthesis radical activating enzyme QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.639 |
| folE | queF | SO_4254 | SO_1608 | GTP cyclohydrolase I FolE. | NADPH-dependent preQ0 reductase QueF; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.637 |
| gspM | queD | SO_0175 | SO_2179 | T2aSS secretion system inner membrane platform protein GspM; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. | Queosine biosynthesis protein QueD. | 0.593 |
| hisIE | cysS | SO_2067 | SO_1791 | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase HisIE; In the C-terminal section; belongs to the PRA-PH family. | cysteinyl-tRNA synthetase CysS; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.679 |
| hisIE | folE | SO_2067 | SO_4254 | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase HisIE; In the C-terminal section; belongs to the PRA-PH family. | GTP cyclohydrolase I FolE. | 0.546 |
| hisIE | queD | SO_2067 | SO_2179 | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase HisIE; In the C-terminal section; belongs to the PRA-PH family. | Queosine biosynthesis protein QueD. | 0.677 |
| nrdG | queC | SO_2833 | SO_2503 | Anaerobic ribonucleoside-triphosphate reductase activating protein NrdG; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | Queuosine biosynthesis ATPase QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.711 |
| nrdG | queD | SO_2833 | SO_2179 | Anaerobic ribonucleoside-triphosphate reductase activating protein NrdG; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | Queosine biosynthesis protein QueD. | 0.824 |
| nrdG | queF | SO_2833 | SO_1608 | Anaerobic ribonucleoside-triphosphate reductase activating protein NrdG; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | NADPH-dependent preQ0 reductase QueF; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.903 |
| queC | SO_2535 | SO_2503 | SO_2535 | Queuosine biosynthesis ATPase QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | Glutamine amidotransferase class II. | 0.971 |