| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SO_2180 | queD | SO_2180 | SO_2179 | Periplasmic metalloprotease M23B family. | Queosine biosynthesis protein QueD. | 0.544 |
| SO_2504 | gspM | SO_2504 | SO_0175 | Rhombosortase. | T2aSS secretion system inner membrane platform protein GspM; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. | 0.761 |
| SO_2504 | queC | SO_2504 | SO_2503 | Rhombosortase. | Queuosine biosynthesis ATPase QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.777 |
| SO_2504 | queD | SO_2504 | SO_2179 | Rhombosortase. | Queosine biosynthesis protein QueD. | 0.572 |
| SO_2504 | queE | SO_2504 | SO_2501 | Rhombosortase. | Queuosine biosynthesis radical activating enzyme QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.516 |
| SO_2535 | folE | SO_2535 | SO_4254 | Glutamine amidotransferase class II. | GTP cyclohydrolase I FolE. | 0.918 |
| SO_2535 | queC | SO_2535 | SO_2503 | Glutamine amidotransferase class II. | Queuosine biosynthesis ATPase QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.922 |
| SO_2535 | queD | SO_2535 | SO_2179 | Glutamine amidotransferase class II. | Queosine biosynthesis protein QueD. | 0.922 |
| cysS | queD | SO_1791 | SO_2179 | cysteinyl-tRNA synthetase CysS; Belongs to the class-I aminoacyl-tRNA synthetase family. | Queosine biosynthesis protein QueD. | 0.640 |
| folE | SO_2535 | SO_4254 | SO_2535 | GTP cyclohydrolase I FolE. | Glutamine amidotransferase class II. | 0.918 |
| folE | nrdG | SO_4254 | SO_2833 | GTP cyclohydrolase I FolE. | Anaerobic ribonucleoside-triphosphate reductase activating protein NrdG; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | 0.416 |
| folE | queC | SO_4254 | SO_2503 | GTP cyclohydrolase I FolE. | Queuosine biosynthesis ATPase QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.950 |
| folE | queD | SO_4254 | SO_2179 | GTP cyclohydrolase I FolE. | Queosine biosynthesis protein QueD. | 0.986 |
| folE | queE | SO_4254 | SO_2501 | GTP cyclohydrolase I FolE. | Queuosine biosynthesis radical activating enzyme QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.547 |
| folE | queF | SO_4254 | SO_1608 | GTP cyclohydrolase I FolE. | NADPH-dependent preQ0 reductase QueF; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). | 0.492 |
| gspM | SO_2504 | SO_0175 | SO_2504 | T2aSS secretion system inner membrane platform protein GspM; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. | Rhombosortase. | 0.761 |
| gspM | queD | SO_0175 | SO_2179 | T2aSS secretion system inner membrane platform protein GspM; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. | Queosine biosynthesis protein QueD. | 0.593 |
| nrdG | folE | SO_2833 | SO_4254 | Anaerobic ribonucleoside-triphosphate reductase activating protein NrdG; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | GTP cyclohydrolase I FolE. | 0.416 |
| nrdG | queC | SO_2833 | SO_2503 | Anaerobic ribonucleoside-triphosphate reductase activating protein NrdG; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | Queuosine biosynthesis ATPase QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.670 |
| nrdG | queD | SO_2833 | SO_2179 | Anaerobic ribonucleoside-triphosphate reductase activating protein NrdG; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. | Queosine biosynthesis protein QueD. | 0.825 |