| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| argR | hexR | SO_0769 | SO_2490 | Arginine-responsive transcriptional repressor of arginine metabolism ArgR; Regulates arginine biosynthesis genes. | RpiR family transcriptional regulator, carbohydrate utilization regulator; 2-keto-3-deoxy-6-phosphogluconate-responsive transcriptional regulator of central carbohydrate metabolism HexR. | 0.650 |
| argR | nrdR | SO_0769 | SO_3470 | Arginine-responsive transcriptional repressor of arginine metabolism ArgR; Regulates arginine biosynthesis genes. | Transcriptional repressor of deoxyribonucleotide biosynthesis NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.824 |
| argR | nrtR | SO_0769 | SO_1979 | Arginine-responsive transcriptional repressor of arginine metabolism ArgR; Regulates arginine biosynthesis genes. | Transcriptional repressor of nicotinamide riboside utilization NrtR. | 0.717 |
| argR | psrA | SO_0769 | SO_2493 | Arginine-responsive transcriptional repressor of arginine metabolism ArgR; Regulates arginine biosynthesis genes. | Transcriptional repressor of fatty acid degradation PsrA. | 0.587 |
| eda | edd | SO_2486 | SO_2487 | Bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase Eda. | 6-phosphogluconate dehydratase Edd; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.999 |
| eda | hexR | SO_2486 | SO_2490 | Bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase Eda. | RpiR family transcriptional regulator, carbohydrate utilization regulator; 2-keto-3-deoxy-6-phosphogluconate-responsive transcriptional regulator of central carbohydrate metabolism HexR. | 0.939 |
| eda | ptsG | SO_2486 | SO_1623 | Bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase Eda. | Phosphotransferase system (PTS) glucose-specific IIBC component PtsG. | 0.892 |
| eda | pykA | SO_2486 | SO_2491 | Bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase Eda. | Pyruvate kinase II PykA; Belongs to the pyruvate kinase family. | 0.982 |
| eda | zwf | SO_2486 | SO_2489 | Bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase Eda. | Glucose-6-phosphate 1-dehydrogenase Zwf; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.989 |
| edd | eda | SO_2487 | SO_2486 | 6-phosphogluconate dehydratase Edd; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase Eda. | 0.999 |
| edd | hexR | SO_2487 | SO_2490 | 6-phosphogluconate dehydratase Edd; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | RpiR family transcriptional regulator, carbohydrate utilization regulator; 2-keto-3-deoxy-6-phosphogluconate-responsive transcriptional regulator of central carbohydrate metabolism HexR. | 0.850 |
| edd | pykA | SO_2487 | SO_2491 | 6-phosphogluconate dehydratase Edd; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Pyruvate kinase II PykA; Belongs to the pyruvate kinase family. | 0.847 |
| edd | zwf | SO_2487 | SO_2489 | 6-phosphogluconate dehydratase Edd; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | Glucose-6-phosphate 1-dehydrogenase Zwf; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. | 0.997 |
| hexR | argR | SO_2490 | SO_0769 | RpiR family transcriptional regulator, carbohydrate utilization regulator; 2-keto-3-deoxy-6-phosphogluconate-responsive transcriptional regulator of central carbohydrate metabolism HexR. | Arginine-responsive transcriptional repressor of arginine metabolism ArgR; Regulates arginine biosynthesis genes. | 0.650 |
| hexR | eda | SO_2490 | SO_2486 | RpiR family transcriptional regulator, carbohydrate utilization regulator; 2-keto-3-deoxy-6-phosphogluconate-responsive transcriptional regulator of central carbohydrate metabolism HexR. | Bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase Eda. | 0.939 |
| hexR | edd | SO_2490 | SO_2487 | RpiR family transcriptional regulator, carbohydrate utilization regulator; 2-keto-3-deoxy-6-phosphogluconate-responsive transcriptional regulator of central carbohydrate metabolism HexR. | 6-phosphogluconate dehydratase Edd; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. | 0.850 |
| hexR | nrdR | SO_2490 | SO_3470 | RpiR family transcriptional regulator, carbohydrate utilization regulator; 2-keto-3-deoxy-6-phosphogluconate-responsive transcriptional regulator of central carbohydrate metabolism HexR. | Transcriptional repressor of deoxyribonucleotide biosynthesis NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.648 |
| hexR | nrtR | SO_2490 | SO_1979 | RpiR family transcriptional regulator, carbohydrate utilization regulator; 2-keto-3-deoxy-6-phosphogluconate-responsive transcriptional regulator of central carbohydrate metabolism HexR. | Transcriptional repressor of nicotinamide riboside utilization NrtR. | 0.662 |
| hexR | pntB | SO_2490 | SO_3741 | RpiR family transcriptional regulator, carbohydrate utilization regulator; 2-keto-3-deoxy-6-phosphogluconate-responsive transcriptional regulator of central carbohydrate metabolism HexR. | NAD(P) transhydrogenase beta subunit PntB; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.708 |
| hexR | psrA | SO_2490 | SO_2493 | RpiR family transcriptional regulator, carbohydrate utilization regulator; 2-keto-3-deoxy-6-phosphogluconate-responsive transcriptional regulator of central carbohydrate metabolism HexR. | Transcriptional repressor of fatty acid degradation PsrA. | 0.776 |