node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SO_3442 | dcd | SO_3442 | SO_2616 | Nucleoside triphosphate pyrophosphohydrolase. | Deoxycytidine triphosphate deaminase Dcd; Catalyzes the deamination of dCTP to dUTP. | 0.917 |
SO_3442 | ndk | SO_3442 | SO_2274 | Nucleoside triphosphate pyrophosphohydrolase. | Nucleoside diphosphate kinase Ndk; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.900 |
SO_3442 | nrdD | SO_3442 | SO_2834 | Nucleoside triphosphate pyrophosphohydrolase. | Anaerobic ribonucleoside-triphosphate reductase NrdD. | 0.900 |
SO_3442 | pyrG | SO_3442 | SO_3441 | Nucleoside triphosphate pyrophosphohydrolase. | CTP synthase PyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.954 |
SO_3442 | thyA | SO_3442 | SO_1335 | Nucleoside triphosphate pyrophosphohydrolase. | Thymidylate synthase ThyA; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.618 |
SO_3442 | udk | SO_3442 | SO_2617 | Nucleoside triphosphate pyrophosphohydrolase. | Uridine kinase Udk. | 0.902 |
dcd | SO_3442 | SO_2616 | SO_3442 | Deoxycytidine triphosphate deaminase Dcd; Catalyzes the deamination of dCTP to dUTP. | Nucleoside triphosphate pyrophosphohydrolase. | 0.917 |
dcd | dut | SO_2616 | SO_4250 | Deoxycytidine triphosphate deaminase Dcd; Catalyzes the deamination of dCTP to dUTP. | Deoxyuridine 5-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.928 |
dcd | ndk | SO_2616 | SO_2274 | Deoxycytidine triphosphate deaminase Dcd; Catalyzes the deamination of dCTP to dUTP. | Nucleoside diphosphate kinase Ndk; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.928 |
dcd | nrdD | SO_2616 | SO_2834 | Deoxycytidine triphosphate deaminase Dcd; Catalyzes the deamination of dCTP to dUTP. | Anaerobic ribonucleoside-triphosphate reductase NrdD. | 0.903 |
dcd | pabC | SO_2616 | SO_2615 | Deoxycytidine triphosphate deaminase Dcd; Catalyzes the deamination of dCTP to dUTP. | Aminodeoxychorismate lyase PabC. | 0.780 |
dcd | pyrG | SO_2616 | SO_3441 | Deoxycytidine triphosphate deaminase Dcd; Catalyzes the deamination of dCTP to dUTP. | CTP synthase PyrG; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.924 |
dcd | thyA | SO_2616 | SO_1335 | Deoxycytidine triphosphate deaminase Dcd; Catalyzes the deamination of dCTP to dUTP. | Thymidylate synthase ThyA; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.858 |
dcd | tmk | SO_2616 | SO_2613 | Deoxycytidine triphosphate deaminase Dcd; Catalyzes the deamination of dCTP to dUTP. | Thymidylate kinase Tmk; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.879 |
dcd | udk | SO_2616 | SO_2617 | Deoxycytidine triphosphate deaminase Dcd; Catalyzes the deamination of dCTP to dUTP. | Uridine kinase Udk. | 0.874 |
dcd | yceG | SO_2616 | SO_2614 | Deoxycytidine triphosphate deaminase Dcd; Catalyzes the deamination of dCTP to dUTP. | Protein YceG; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. | 0.779 |
dut | dcd | SO_4250 | SO_2616 | Deoxyuridine 5-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Deoxycytidine triphosphate deaminase Dcd; Catalyzes the deamination of dCTP to dUTP. | 0.928 |
dut | ndk | SO_4250 | SO_2274 | Deoxyuridine 5-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Nucleoside diphosphate kinase Ndk; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.940 |
dut | nrdD | SO_4250 | SO_2834 | Deoxyuridine 5-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Anaerobic ribonucleoside-triphosphate reductase NrdD. | 0.916 |
dut | thyA | SO_4250 | SO_1335 | Deoxyuridine 5-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase ThyA; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.974 |