Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ldhLeucine dehydrogenase Ldh. (344 aa)    
Predicted Functional Partners:
bkdA1
3-methyl-2-oxobutanoate dehydrogenase complex E1 component alpha subunit BkdA1.
  
 
 0.972
bkdA2
3-methyl-2-oxobutanoate dehydrogenase complex E1 component beta subunit BkdA2.
  
 
 0.962
ilvE
Branched-chain-amino-acid transaminase IlvE.
  
 
 0.939
yfbQ
PLP-dependent aminotransferase YfbQ.
  
 
 0.925
ilvD
Dihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family.
   
 
 0.913
leuA
2-isopropylmalate synthase LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 
 0.912
gltB
NADPH-dependent glutamate synthase large subunit GltB.
  
 
 0.890
SO_0827
Lactate transport protein LctP family; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family.
   
  
 0.810
SO_1522
Lactate transport protein LctP family; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family.
      
 0.804
lldE
L-lactate dehydrogenase complex protein LldE.
      
 0.792
Your Current Organism:
Shewanella oneidensis
NCBI taxonomy Id: 211586
Other names: S. oneidensis MR-1, Shewanella oneidensis ATCC 700550, Shewanella oneidensis MR-1, Shewanella oneidensis str. MR-1, Shewanella oneidensis strain MR-1, Shewanella sp. MR-1
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