| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SO_2380 | dinG | SO_2380 | SO_1819 | ATP-dependent DNA helicase RecQ family. | ATP-dependent helicase DinG; DNA-dependent ATPase and 5'-3' DNA helicase. | 0.542 |
| SO_2380 | gyrB | SO_2380 | SO_0011 | ATP-dependent DNA helicase RecQ family. | DNA gyrase B subunit GyrB; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.436 |
| SO_2380 | recA | SO_2380 | SO_3430 | ATP-dependent DNA helicase RecQ family. | Recombinase A RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.899 |
| SO_2380 | recQ | SO_2380 | SO_4241 | ATP-dependent DNA helicase RecQ family. | ATP-dependent DNA helicase RecQ. | 0.920 |
| SO_2380 | topA | SO_2380 | SO_2705 | ATP-dependent DNA helicase RecQ family. | DNA topoisomerase I TopA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA [...] | 0.964 |
| dinG | SO_2380 | SO_1819 | SO_2380 | ATP-dependent helicase DinG; DNA-dependent ATPase and 5'-3' DNA helicase. | ATP-dependent DNA helicase RecQ family. | 0.542 |
| dinG | recA | SO_1819 | SO_3430 | ATP-dependent helicase DinG; DNA-dependent ATPase and 5'-3' DNA helicase. | Recombinase A RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.734 |
| dinG | recN | SO_1819 | SO_3462 | ATP-dependent helicase DinG; DNA-dependent ATPase and 5'-3' DNA helicase. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.690 |
| dinG | recQ | SO_1819 | SO_4241 | ATP-dependent helicase DinG; DNA-dependent ATPase and 5'-3' DNA helicase. | ATP-dependent DNA helicase RecQ. | 0.678 |
| dinG | rpoA | SO_1819 | SO_0256 | ATP-dependent helicase DinG; DNA-dependent ATPase and 5'-3' DNA helicase. | DNA-directed RNA polymerase alpha subunit RpoA; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.887 |
| dinG | topA | SO_1819 | SO_2705 | ATP-dependent helicase DinG; DNA-dependent ATPase and 5'-3' DNA helicase. | DNA topoisomerase I TopA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA [...] | 0.834 |
| gltB | gyrB | SO_1325 | SO_0011 | NADPH-dependent glutamate synthase large subunit GltB. | DNA gyrase B subunit GyrB; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.515 |
| gltB | recA | SO_1325 | SO_3430 | NADPH-dependent glutamate synthase large subunit GltB. | Recombinase A RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.426 |
| gltB | ssb | SO_1325 | SO_4028 | NADPH-dependent glutamate synthase large subunit GltB. | Single-strand binding protein Ssb; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. | 0.504 |
| gltB | topA | SO_1325 | SO_2705 | NADPH-dependent glutamate synthase large subunit GltB. | DNA topoisomerase I TopA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA [...] | 0.922 |
| gyrB | SO_2380 | SO_0011 | SO_2380 | DNA gyrase B subunit GyrB; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | ATP-dependent DNA helicase RecQ family. | 0.436 |
| gyrB | gltB | SO_0011 | SO_1325 | DNA gyrase B subunit GyrB; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | NADPH-dependent glutamate synthase large subunit GltB. | 0.515 |
| gyrB | leuS | SO_0011 | SO_1174 | DNA gyrase B subunit GyrB; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | leucyl-tRNA synthetase LeuS; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.404 |
| gyrB | recA | SO_0011 | SO_3430 | DNA gyrase B subunit GyrB; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Recombinase A RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.819 |
| gyrB | recN | SO_0011 | SO_3462 | DNA gyrase B subunit GyrB; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.577 |
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