node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SO_2017 | clpA | SO_2017 | SO_2626 | Heat shock response protein. | ATP-dependent Clp protease ATPase and specificity subunit ClpA; Belongs to the ClpA/ClpB family. | 0.440 |
SO_2017 | clpB | SO_2017 | SO_3577 | Heat shock response protein. | Stress-induced multi-chaperone system component ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to [...] | 0.580 |
SO_2017 | ftsH | SO_2017 | SO_1197 | Heat shock response protein. | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.415 |
SO_2017 | grpE | SO_2017 | SO_1524 | Heat shock response protein. | Heat shock nucleotide exchange factor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Sev [...] | 0.907 |
SO_2017 | htpX | SO_2017 | SO_2728 | Heat shock response protein. | Zn-dependent metalloprotease HtpX; Belongs to the peptidase M48B family. | 0.588 |
SO_4812 | htpX | SO_4812 | SO_2728 | Protein of unknown function. | Zn-dependent metalloprotease HtpX; Belongs to the peptidase M48B family. | 0.566 |
clpA | SO_2017 | SO_2626 | SO_2017 | ATP-dependent Clp protease ATPase and specificity subunit ClpA; Belongs to the ClpA/ClpB family. | Heat shock response protein. | 0.440 |
clpA | ftsH | SO_2626 | SO_1197 | ATP-dependent Clp protease ATPase and specificity subunit ClpA; Belongs to the ClpA/ClpB family. | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.639 |
clpA | grpE | SO_2626 | SO_1524 | ATP-dependent Clp protease ATPase and specificity subunit ClpA; Belongs to the ClpA/ClpB family. | Heat shock nucleotide exchange factor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Sev [...] | 0.921 |
clpA | hflC | SO_2626 | SO_0606 | ATP-dependent Clp protease ATPase and specificity subunit ClpA; Belongs to the ClpA/ClpB family. | Membrane anchored FtsH modulator component 2 HflC; HflC and HflK could regulate a protease. | 0.511 |
clpA | hflK | SO_2626 | SO_0605 | ATP-dependent Clp protease ATPase and specificity subunit ClpA; Belongs to the ClpA/ClpB family. | Membrane anchored FtsH modulator component 1 HflK; HflC and HflK could encode or regulate a protease. | 0.514 |
clpA | htpX | SO_2626 | SO_2728 | ATP-dependent Clp protease ATPase and specificity subunit ClpA; Belongs to the ClpA/ClpB family. | Zn-dependent metalloprotease HtpX; Belongs to the peptidase M48B family. | 0.696 |
clpB | SO_2017 | SO_3577 | SO_2017 | Stress-induced multi-chaperone system component ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to [...] | Heat shock response protein. | 0.580 |
clpB | ftsH | SO_3577 | SO_1197 | Stress-induced multi-chaperone system component ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to [...] | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.430 |
clpB | grpE | SO_3577 | SO_1524 | Stress-induced multi-chaperone system component ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to [...] | Heat shock nucleotide exchange factor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Sev [...] | 0.962 |
clpB | htpX | SO_3577 | SO_2728 | Stress-induced multi-chaperone system component ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to [...] | Zn-dependent metalloprotease HtpX; Belongs to the peptidase M48B family. | 0.553 |
cpxP | htpX | SO_4476 | SO_2728 | Periplasmic stress adaptor protein CpxP. | Zn-dependent metalloprotease HtpX; Belongs to the peptidase M48B family. | 0.825 |
ftsH | SO_2017 | SO_1197 | SO_2017 | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Heat shock response protein. | 0.415 |
ftsH | clpA | SO_1197 | SO_2626 | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | ATP-dependent Clp protease ATPase and specificity subunit ClpA; Belongs to the ClpA/ClpB family. | 0.639 |
ftsH | clpB | SO_1197 | SO_3577 | ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Stress-induced multi-chaperone system component ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to [...] | 0.430 |