node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aptA | bioB | SO_3497 | SO_2740 | Beta-alanine-pyruvate transaminase AptA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.924 |
aptA | bioD | SO_3497 | SO_2737 | Beta-alanine-pyruvate transaminase AptA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.824 |
aptA | bioF | SO_3497 | SO_2739 | Beta-alanine-pyruvate transaminase AptA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 8-amino-7-oxononanoate synthase BioF. | 0.580 |
aptA | birA | SO_3497 | SO_0214 | Beta-alanine-pyruvate transaminase AptA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Bifunctional biotin operon repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.478 |
aptA | hydE | SO_3497 | SO_3925 | Beta-alanine-pyruvate transaminase AptA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Fe hydrogenase maturation rSAM protein HydE. | 0.655 |
aptA | kbl | SO_3497 | SO_4674 | Beta-alanine-pyruvate transaminase AptA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 2-amino-3-ketobutyrate coenzyme A ligase Kbl; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.565 |
aptA | thiDE | SO_3497 | SO_2444 | Beta-alanine-pyruvate transaminase AptA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Bifunctional hydroxy-(phospho)methylpyrimidine kinase/thiamine-phosphate pyrophosphorylase ThiDE; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.402 |
argD | bioB | SO_0617 | SO_2740 | Bifunctional acetylornithine aminotransferase/succinyl-diaminopimelate aminotransferase/succinylornithine transaminase ArgD; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | Biotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.592 |
argD | bioC | SO_0617 | SO_2738 | Bifunctional acetylornithine aminotransferase/succinyl-diaminopimelate aminotransferase/succinylornithine transaminase ArgD; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | SAM-dependent methylase involved in biotin synthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.403 |
argD | bioD | SO_0617 | SO_2737 | Bifunctional acetylornithine aminotransferase/succinyl-diaminopimelate aminotransferase/succinylornithine transaminase ArgD; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | Dethiobiotin synthase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.418 |
argD | kbl | SO_0617 | SO_4674 | Bifunctional acetylornithine aminotransferase/succinyl-diaminopimelate aminotransferase/succinylornithine transaminase ArgD; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. | 2-amino-3-ketobutyrate coenzyme A ligase Kbl; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.400 |
bioA | bioB | SO_2741 | SO_2740 | Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.995 |
bioA | bioC | SO_2741 | SO_2738 | Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | SAM-dependent methylase involved in biotin synthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.538 |
bioA | bioD | SO_2741 | SO_2737 | Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.999 |
bioA | bioF | SO_2741 | SO_2739 | Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 8-amino-7-oxononanoate synthase BioF. | 0.997 |
bioA | birA | SO_2741 | SO_0214 | Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Bifunctional biotin operon repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.720 |
bioA | hydE | SO_2741 | SO_3925 | Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Fe hydrogenase maturation rSAM protein HydE. | 0.655 |
bioA | kbl | SO_2741 | SO_4674 | Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 2-amino-3-ketobutyrate coenzyme A ligase Kbl; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.741 |
bioA | thiDE | SO_2741 | SO_2444 | Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Bifunctional hydroxy-(phospho)methylpyrimidine kinase/thiamine-phosphate pyrophosphorylase ThiDE; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.573 |
bioB | aptA | SO_2740 | SO_3497 | Biotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Beta-alanine-pyruvate transaminase AptA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.924 |