| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SO_1292 | folE | SO_1292 | SO_4254 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK-like protein. | GTP cyclohydrolase I FolE. | 0.919 |
| SO_1292 | folP | SO_1292 | SO_1198 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK-like protein. | Dihydropteroate synthase FolP; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.996 |
| SO_1292 | folX | SO_1292 | SO_2921 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK-like protein. | D-erythro-78-dihydroneopterin triphosphate epimerase FolX. | 0.812 |
| cobS | folM | SO_1036 | SO_0772 | Cobalamin 5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | Dihydrofolate reductase FolM. | 0.750 |
| cobS | folX | SO_1036 | SO_2921 | Cobalamin 5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | D-erythro-78-dihydroneopterin triphosphate epimerase FolX. | 0.815 |
| cobS | nfnB | SO_1036 | SO_3715 | Cobalamin 5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | Bifunctional oxygen-insensitive NAD(P)H nitroreductase/dihydropteridine reductase NfnB. | 0.722 |
| cobS | rfbc | SO_1036 | SO_3160 | Cobalamin 5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | dTDP-4-keto-L-rhamnose-35-epimerase RfbC; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. | 0.806 |
| folE | SO_1292 | SO_4254 | SO_1292 | GTP cyclohydrolase I FolE. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK-like protein. | 0.919 |
| folE | folM | SO_4254 | SO_0772 | GTP cyclohydrolase I FolE. | Dihydrofolate reductase FolM. | 0.402 |
| folE | folP | SO_4254 | SO_1198 | GTP cyclohydrolase I FolE. | Dihydropteroate synthase FolP; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.983 |
| folE | folX | SO_4254 | SO_2921 | GTP cyclohydrolase I FolE. | D-erythro-78-dihydroneopterin triphosphate epimerase FolX. | 0.991 |
| folE | phoA | SO_4254 | SO_0830 | GTP cyclohydrolase I FolE. | Periplasmic alkaline phosphatase PhoA; Belongs to the alkaline phosphatase family. | 0.900 |
| folE | phoD | SO_4254 | SO_0806 | GTP cyclohydrolase I FolE. | Ca(2+)-dependent phospholipase D PhoD. | 0.915 |
| folM | cobS | SO_0772 | SO_1036 | Dihydrofolate reductase FolM. | Cobalamin 5-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.750 |
| folM | folE | SO_0772 | SO_4254 | Dihydrofolate reductase FolM. | GTP cyclohydrolase I FolE. | 0.402 |
| folM | folP | SO_0772 | SO_1198 | Dihydrofolate reductase FolM. | Dihydropteroate synthase FolP; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.698 |
| folM | folX | SO_0772 | SO_2921 | Dihydrofolate reductase FolM. | D-erythro-78-dihydroneopterin triphosphate epimerase FolX. | 0.917 |
| folM | nfnB | SO_0772 | SO_3715 | Dihydrofolate reductase FolM. | Bifunctional oxygen-insensitive NAD(P)H nitroreductase/dihydropteridine reductase NfnB. | 0.691 |
| folM | rfbc | SO_0772 | SO_3160 | Dihydrofolate reductase FolM. | dTDP-4-keto-L-rhamnose-35-epimerase RfbC; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. | 0.710 |
| folP | SO_1292 | SO_1198 | SO_1292 | Dihydropteroate synthase FolP; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK-like protein. | 0.996 |