STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SO_3108Bifunctional 13-dimethyluroporphyrinogen III dehydrogenase/siroheme ferrochelatase. (303 aa)    
Predicted Functional Partners:
cysG
uroporphyrin-III C-methyltransferase CysG; Belongs to the precorrin methyltransferase family.
 
 0.999
bioA
Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
   
  
 0.927
hemX
uroporphyrin-III C-methyltransferase HemX.
     
 0.901
hemL
Glutamate-1-semialdehyde-21-aminomutase HemL.
   
 0.816
hemC
Hydroxymethylbilane synthase HemC; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.750
cysI
Sulfite reductase (NADPH) siroheme FeS subunit CysI; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.689
cysH
Phosphoadenylyl-sulfate reductase thioredoxin-dependent CysH; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.637
cysC
Adenylylsulfate kinase CysC; Catalyzes the synthesis of activated sulfate.
  
  
 0.581
metH
B12-dependent 5-methyltetrahydrofolate--homocysteine methyltransferase MetH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
  
 0.559
yaeQ
Protein of unknown function YaeQ.
       0.548
Your Current Organism:
Shewanella oneidensis
NCBI taxonomy Id: 211586
Other names: S. oneidensis MR-1, Shewanella oneidensis ATCC 700550, Shewanella oneidensis MR-1, Shewanella oneidensis str. MR-1, Shewanella oneidensis strain MR-1, Shewanella sp. MR-1
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