node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
birA | garK | SO_0214 | SO_1770 | Bifunctional biotin operon repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Glycerate kinase GarK; Belongs to the glycerate kinase type-1 family. | 0.543 |
birA | guaA | SO_0214 | SO_3292 | Bifunctional biotin operon repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | GMP synthase (glutamine-hydrolysing) GuaA; Catalyzes the synthesis of GMP from XMP. | 0.536 |
birA | guaB | SO_0214 | SO_3293 | Bifunctional biotin operon repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Inosine-5-monophosphate dehydrogenase GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.673 |
birA | tadA | SO_0214 | SO_3291 | Bifunctional biotin operon repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | tRNA-specific adenosine deaminase TadA; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.866 |
birA | yeaZ | SO_0214 | SO_2586 | Bifunctional biotin operon repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | YgjD protease YeaZ. | 0.933 |
fieF | tadA | SO_4475 | SO_3291 | Cadmium and zinc efflux pump FieF; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. | tRNA-specific adenosine deaminase TadA; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.729 |
garK | birA | SO_1770 | SO_0214 | Glycerate kinase GarK; Belongs to the glycerate kinase type-1 family. | Bifunctional biotin operon repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.543 |
garK | tadA | SO_1770 | SO_3291 | Glycerate kinase GarK; Belongs to the glycerate kinase type-1 family. | tRNA-specific adenosine deaminase TadA; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.903 |
guaA | birA | SO_3292 | SO_0214 | GMP synthase (glutamine-hydrolysing) GuaA; Catalyzes the synthesis of GMP from XMP. | Bifunctional biotin operon repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.536 |
guaA | guaB | SO_3292 | SO_3293 | GMP synthase (glutamine-hydrolysing) GuaA; Catalyzes the synthesis of GMP from XMP. | Inosine-5-monophosphate dehydrogenase GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | tadA | SO_3292 | SO_3291 | GMP synthase (glutamine-hydrolysing) GuaA; Catalyzes the synthesis of GMP from XMP. | tRNA-specific adenosine deaminase TadA; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.695 |
guaA | yeaZ | SO_3292 | SO_2586 | GMP synthase (glutamine-hydrolysing) GuaA; Catalyzes the synthesis of GMP from XMP. | YgjD protease YeaZ. | 0.474 |
guaB | birA | SO_3293 | SO_0214 | Inosine-5-monophosphate dehydrogenase GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Bifunctional biotin operon repressor/biotin-[acetyl-CoA-carboxylase] ligase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.673 |
guaB | guaA | SO_3293 | SO_3292 | Inosine-5-monophosphate dehydrogenase GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase (glutamine-hydrolysing) GuaA; Catalyzes the synthesis of GMP from XMP. | 0.999 |
guaB | hisIE | SO_3293 | SO_2067 | Inosine-5-monophosphate dehydrogenase GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase HisIE; In the C-terminal section; belongs to the PRA-PH family. | 0.506 |
guaB | tadA | SO_3293 | SO_3291 | Inosine-5-monophosphate dehydrogenase GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | tRNA-specific adenosine deaminase TadA; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.616 |
hisIE | guaB | SO_2067 | SO_3293 | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase HisIE; In the C-terminal section; belongs to the PRA-PH family. | Inosine-5-monophosphate dehydrogenase GuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.506 |
hisIE | tadA | SO_2067 | SO_3291 | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase HisIE; In the C-terminal section; belongs to the PRA-PH family. | tRNA-specific adenosine deaminase TadA; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.894 |
hisIE | yeaZ | SO_2067 | SO_2586 | Bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase HisIE; In the C-terminal section; belongs to the PRA-PH family. | YgjD protease YeaZ. | 0.936 |
rsmI | tadA | SO_0301 | SO_3291 | 16S rRNA (cytidine1402-2'-O)-methyltransferase RsmI; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. | tRNA-specific adenosine deaminase TadA; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.581 |