| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SO_3635 | ampG | SO_3635 | SO_3814 | Cell wall phosphotransferase. | GlcNAc-anhMurNAc permease AmpG. | 0.548 |
| SO_3635 | nagZ | SO_3635 | SO_2250 | Cell wall phosphotransferase. | beta-N-acetylglucosaminidase NagZ; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.942 |
| ampC | ampD | SO_2388 | SO_0421 | Class C beta-lactamase AmpC. | N-acetyl-anhydromuramyl-L-alanine amidase AmpD. | 0.918 |
| ampC | ampG | SO_2388 | SO_3814 | Class C beta-lactamase AmpC. | GlcNAc-anhMurNAc permease AmpG. | 0.915 |
| ampC | ampP | SO_2388 | SO_1388 | Class C beta-lactamase AmpC. | Aminopeptidase P AmpP. | 0.491 |
| ampC | anmK | SO_2388 | SO_1313 | Class C beta-lactamase AmpC. | anhydro-N-acetylmuramic acid kinase AnmK; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.681 |
| ampC | blaA | SO_2388 | SO_0837 | Class C beta-lactamase AmpC. | Class D carbapenem-hydrolyzing beta-lactamase BlaA. | 0.922 |
| ampC | mcrA | SO_2388 | SO_0280 | Class C beta-lactamase AmpC. | Penicillin-binding protein 1A McrA. | 0.621 |
| ampC | mrcB | SO_2388 | SO_0633 | Class C beta-lactamase AmpC. | Penicillin-binding protein 1B MrcB; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.530 |
| ampC | nagZ | SO_2388 | SO_2250 | Class C beta-lactamase AmpC. | beta-N-acetylglucosaminidase NagZ; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.876 |
| ampD | ampC | SO_0421 | SO_2388 | N-acetyl-anhydromuramyl-L-alanine amidase AmpD. | Class C beta-lactamase AmpC. | 0.918 |
| ampD | ampG | SO_0421 | SO_3814 | N-acetyl-anhydromuramyl-L-alanine amidase AmpD. | GlcNAc-anhMurNAc permease AmpG. | 0.941 |
| ampD | anmK | SO_0421 | SO_1313 | N-acetyl-anhydromuramyl-L-alanine amidase AmpD. | anhydro-N-acetylmuramic acid kinase AnmK; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. | 0.894 |
| ampD | blaA | SO_0421 | SO_0837 | N-acetyl-anhydromuramyl-L-alanine amidase AmpD. | Class D carbapenem-hydrolyzing beta-lactamase BlaA. | 0.788 |
| ampD | mrcB | SO_0421 | SO_0633 | N-acetyl-anhydromuramyl-L-alanine amidase AmpD. | Penicillin-binding protein 1B MrcB; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.412 |
| ampD | nagZ | SO_0421 | SO_2250 | N-acetyl-anhydromuramyl-L-alanine amidase AmpD. | beta-N-acetylglucosaminidase NagZ; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. | 0.940 |
| ampG | SO_3635 | SO_3814 | SO_3635 | GlcNAc-anhMurNAc permease AmpG. | Cell wall phosphotransferase. | 0.548 |
| ampG | ampC | SO_3814 | SO_2388 | GlcNAc-anhMurNAc permease AmpG. | Class C beta-lactamase AmpC. | 0.915 |
| ampG | ampD | SO_3814 | SO_0421 | GlcNAc-anhMurNAc permease AmpG. | N-acetyl-anhydromuramyl-L-alanine amidase AmpD. | 0.941 |
| ampG | ampP | SO_3814 | SO_1388 | GlcNAc-anhMurNAc permease AmpG. | Aminopeptidase P AmpP. | 0.573 |