STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tolCGlobal secretion system secretin TolC. (435 aa)    
Predicted Functional Partners:
SO_1881
HAE1 family efflux pump MFP component; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.955
vexB
RND-type multidrug/detergent efflux system MFP component VexB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.952
vmeA
Proton-coupled multidrug efflux pump MFP component VmeA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.949
vexA
RND-type multidrug/detergent efflux system permease component VexA; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 0.941
SO_1882
HAE1 family efflux pump permease component; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
 0.934
vmeB
Proton-coupled multidrug efflux pump permease component VmeB.
 
 0.934
macB
ABC-type macrolide export system bifunctional ATPase and permease component MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.933
aggA
Type I protein secretion system secretin component AggA.
  
 
 0.921
macA
ABC-type macrolide export systemMFP component MacA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 0.850
bamA
Beta barrel protein translocation component BamA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
 
   
 0.841
Your Current Organism:
Shewanella oneidensis
NCBI taxonomy Id: 211586
Other names: S. oneidensis MR-1, Shewanella oneidensis ATCC 700550, Shewanella oneidensis MR-1, Shewanella oneidensis str. MR-1, Shewanella oneidensis strain MR-1, Shewanella sp. MR-1
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