STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvYLysR family transcriptional regulator, positive regulator for ilvC; Acetohydroxybutyrate/acetolactate-responsive transcriptional regulator of isoleucine-valine biosynthesis IlvY; Belongs to the LysR transcriptional regulatory family. (290 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
   
 0.868
SO_0997
Transcriptional regulator LysR family; Belongs to the LysR transcriptional regulatory family.
  
     0.737
SO_0989
Transcriptional regulator LysR family; Belongs to the LysR transcriptional regulatory family.
  
     0.735
SO_4140
Transcriptional regulator LysR family; Belongs to the LysR transcriptional regulatory family.
  
     0.734
gcvA
Transcriptional activator of glycine metabolism GcvA; Belongs to the LysR transcriptional regulatory family.
  
   
 0.715
SO_4524
Transcriptional regulator LysR family; Belongs to the LysR transcriptional regulatory family.
  
     0.694
lldR
Transcriptional regulator of L-lactate utilization LldR; Belongs to the LysR transcriptional regulatory family.
  
    0.676
hmgR
Homogentisate-responsive transcriptional repressor of homogenetisate degradation HmgR; Belongs to the LysR transcriptional regulatory family.
  
     0.644
ilvA
Threonine dehydratase IlvA; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
     
 0.634
SO_2053
Transcriptional regulator LysR family; Belongs to the LysR transcriptional regulatory family.
  
    0.626
Your Current Organism:
Shewanella oneidensis
NCBI taxonomy Id: 211586
Other names: S. oneidensis MR-1, Shewanella oneidensis ATCC 700550, Shewanella oneidensis MR-1, Shewanella oneidensis str. MR-1, Shewanella oneidensis strain MR-1, Shewanella sp. MR-1
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