node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SO_4399 | SO_4400 | SO_4399 | SO_4400 | Protein of unknown function. | Prolyl aminopeptidase S33 family; Belongs to the peptidase S33 family. | 0.773 |
SO_4399 | dtd | SO_4399 | SO_4398 | Protein of unknown function. | D-tyrosyl-tRNA(Tyr) deacylase Dtd; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | 0.756 |
SO_4399 | yiiD | SO_4399 | SO_4397 | Protein of unknown function. | Thioesterase domain protein YiiD. | 0.677 |
SO_4400 | SO_4399 | SO_4400 | SO_4399 | Prolyl aminopeptidase S33 family; Belongs to the peptidase S33 family. | Protein of unknown function. | 0.773 |
SO_4400 | dtd | SO_4400 | SO_4398 | Prolyl aminopeptidase S33 family; Belongs to the peptidase S33 family. | D-tyrosyl-tRNA(Tyr) deacylase Dtd; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | 0.781 |
SO_4400 | yiiD | SO_4400 | SO_4397 | Prolyl aminopeptidase S33 family; Belongs to the peptidase S33 family. | Thioesterase domain protein YiiD. | 0.677 |
acpS | fabD | SO_1352 | SO_2777 | Holo-(acyl-carrier protein) synthase AcpS; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. | Malonyl CoA-acyl carrier protein transacylase FabD. | 0.845 |
acpS | fabG | SO_1352 | SO_2776 | Holo-(acyl-carrier protein) synthase AcpS; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. | 3-oxoacyl-(acyl-carrier-protein) reductase FabG; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.749 |
acpS | fabG-2 | SO_1352 | SO_4382 | Holo-(acyl-carrier protein) synthase AcpS; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. | 3-oxoacyl-(acyl-carrier-protein) reductase FabG. | 0.730 |
acpS | fabH | SO_1352 | SO_2778 | Holo-(acyl-carrier protein) synthase AcpS; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. | 3-oxoacyl-(acyl-carrier-protein) synthase III FabH; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. | 0.665 |
acpS | yiiD | SO_1352 | SO_4397 | Holo-(acyl-carrier protein) synthase AcpS; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. | Thioesterase domain protein YiiD. | 0.783 |
dtd | SO_4399 | SO_4398 | SO_4399 | D-tyrosyl-tRNA(Tyr) deacylase Dtd; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | Protein of unknown function. | 0.756 |
dtd | SO_4400 | SO_4398 | SO_4400 | D-tyrosyl-tRNA(Tyr) deacylase Dtd; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | Prolyl aminopeptidase S33 family; Belongs to the peptidase S33 family. | 0.781 |
dtd | yiiD | SO_4398 | SO_4397 | D-tyrosyl-tRNA(Tyr) deacylase Dtd; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. | Thioesterase domain protein YiiD. | 0.948 |
fabD | acpS | SO_2777 | SO_1352 | Malonyl CoA-acyl carrier protein transacylase FabD. | Holo-(acyl-carrier protein) synthase AcpS; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. | 0.845 |
fabD | fabG | SO_2777 | SO_2776 | Malonyl CoA-acyl carrier protein transacylase FabD. | 3-oxoacyl-(acyl-carrier-protein) reductase FabG; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.996 |
fabD | fabG-2 | SO_2777 | SO_4382 | Malonyl CoA-acyl carrier protein transacylase FabD. | 3-oxoacyl-(acyl-carrier-protein) reductase FabG. | 0.957 |
fabD | fabH | SO_2777 | SO_2778 | Malonyl CoA-acyl carrier protein transacylase FabD. | 3-oxoacyl-(acyl-carrier-protein) synthase III FabH; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. | 0.999 |
fabD | glmU | SO_2777 | SO_4745 | Malonyl CoA-acyl carrier protein transacylase FabD. | Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | 0.625 |
fabD | ybgC | SO_2777 | SO_2752 | Malonyl CoA-acyl carrier protein transacylase FabD. | TolA energy-transducing system-associated acyl-CoA thioesterase YbgC. | 0.499 |