STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glnGDNA-binding transcriptional regulator NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (471 aa)    
Predicted Functional Partners:
glnL
Nitrogen-responsive two component signal transduction system histidine kinase with PAS sensory domain GlnL.
 0.997
rpoN
RNA polymerase sigma-54 factor RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
   
 0.851
lexA
Bifunctional transcriptional repressor of SOS-response/self-cleaving protease LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
  
  
 0.672
SO_0859
Histidine kinase; Two component signal transduction system hybrid histidine kinase/response regulator with PAS sensory domain.
  
 
 0.610
torT
Periplasmic component of the TorRS TMAO sensory system TorT.
   
  
 0.602
torS
Histidine kinase; TMAO-responsive two component signal transduction system hybrid histidine kinase/response regulator TorS.
  
 
 0.599
glnA
Glutamine synthetase GlnA.
  
  
 0.594
cheA
Chemotaxis signal transduction system histidine kinase CheA.
  
 
 0.591
cheA-2
Chemotaxis signal transduction system histidine kinase CheA.
  
 
 0.591
flhA
Flagellar export protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
  
  
 0.590
Your Current Organism:
Shewanella oneidensis
NCBI taxonomy Id: 211586
Other names: S. oneidensis MR-1, Shewanella oneidensis ATCC 700550, Shewanella oneidensis MR-1, Shewanella oneidensis str. MR-1, Shewanella oneidensis strain MR-1, Shewanella sp. MR-1
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.