| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| agxT | gcvH | SO_4343 | SO_0780 | Serine-pyruvate aminotransferase AgxT. | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.918 |
| agxT | gcvP | SO_4343 | SO_0781 | Serine-pyruvate aminotransferase AgxT. | Glycine dehydrogenase (decarboxylating) GcvP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.937 |
| agxT | gcvT | SO_4343 | SO_0779 | Serine-pyruvate aminotransferase AgxT. | Aminomethyltransferase GcvT; The glycine cleavage system catalyzes the degradation of glycine. | 0.948 |
| agxT | glyA | SO_4343 | SO_3471 | Serine-pyruvate aminotransferase AgxT. | Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.967 |
| agxT | kbl | SO_4343 | SO_4674 | Serine-pyruvate aminotransferase AgxT. | 2-amino-3-ketobutyrate coenzyme A ligase Kbl; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.912 |
| agxT | ybjU | SO_4343 | SO_3338 | Serine-pyruvate aminotransferase AgxT. | Threonine aldolase YbjU. | 0.936 |
| bioA | bioD | SO_2741 | SO_2737 | Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.999 |
| bioA | kbl | SO_2741 | SO_4674 | Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 2-amino-3-ketobutyrate coenzyme A ligase Kbl; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.741 |
| bioD | bioA | SO_2737 | SO_2741 | Dethiobiotin synthase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.999 |
| bioD | kbl | SO_2737 | SO_4674 | Dethiobiotin synthase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 2-amino-3-ketobutyrate coenzyme A ligase Kbl; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.828 |
| fabD | kbl | SO_2777 | SO_4674 | Malonyl CoA-acyl carrier protein transacylase FabD. | 2-amino-3-ketobutyrate coenzyme A ligase Kbl; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.750 |
| gcvH | agxT | SO_0780 | SO_4343 | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine-pyruvate aminotransferase AgxT. | 0.918 |
| gcvH | gcvP | SO_0780 | SO_0781 | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase (decarboxylating) GcvP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| gcvH | gcvT | SO_0780 | SO_0779 | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase GcvT; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
| gcvH | glyA | SO_0780 | SO_3471 | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.975 |
| gcvH | kbl | SO_0780 | SO_4674 | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 2-amino-3-ketobutyrate coenzyme A ligase Kbl; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.814 |
| gcvH | tdh | SO_0780 | SO_4673 | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | L-threonine 3-dehydrogenase Tdh; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.520 |
| gcvP | agxT | SO_0781 | SO_4343 | Glycine dehydrogenase (decarboxylating) GcvP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Serine-pyruvate aminotransferase AgxT. | 0.937 |
| gcvP | gcvH | SO_0781 | SO_0780 | Glycine dehydrogenase (decarboxylating) GcvP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine cleavage system carrier of aminomethyl moiety GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
| gcvP | gcvT | SO_0781 | SO_0779 | Glycine dehydrogenase (decarboxylating) GcvP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Aminomethyltransferase GcvT; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |