TOP1MT protein (Accipiter nisus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

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[Homology]

Score

TOP1MT

DNA topoisomerase I mitochondrial. (844 aa)

Predicted Functional Partners:

TDP1

0.925

RNASEH2A

0.909

POLE

0.905

ENSANIP00000009418

0.901

TIMELESS

0.891

PCNA

0.887

TOP2B

0.869

TOP2A

0.869

MRE11

0.863

ENSANIP00000010364

0.861

Your Current Organism:

Accipiter nisus

NCBI taxonomy Id: 211598
Other names: A. nisus, Eurasian sparrowhawk

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSANIP00000009418	MRE11	ENSANIP00000009418	ENSANIP00000014353	annotation not available	MRE11 homolog, double strand break repair nuclease.	0.861
ENSANIP00000009418	PCNA	ENSANIP00000009418	ENSANIP00000014926	annotation not available	Proliferating cell nuclear antigen.	0.893
ENSANIP00000009418	POLE	ENSANIP00000009418	ENSANIP00000002754	annotation not available	DNA polymerase epsilon, catalytic subunit.	0.680
ENSANIP00000009418	RNASEH2A	ENSANIP00000009418	ENSANIP00000025319	annotation not available	Ribonuclease H2 subunit A.	0.621
ENSANIP00000009418	TDP1	ENSANIP00000009418	ENSANIP00000005970	annotation not available	tyrosyl-DNA phosphodiesterase 1.	0.922
ENSANIP00000009418	TIMELESS	ENSANIP00000009418	ENSANIP00000018446	annotation not available	Timeless circadian regulator.	0.871
ENSANIP00000009418	TOP1MT	ENSANIP00000009418	ENSANIP00000001029	annotation not available	DNA topoisomerase I mitochondrial.	0.901
ENSANIP00000009418	TOP2A	ENSANIP00000009418	ENSANIP00000012869	annotation not available	DNA topoisomerase II alpha.	0.463
ENSANIP00000009418	TOP2B	ENSANIP00000009418	ENSANIP00000007037	annotation not available	DNA topoisomerase II beta.	0.463
ENSANIP00000010364	TOP1MT	ENSANIP00000010364	ENSANIP00000001029	annotation not available	DNA topoisomerase I mitochondrial.	0.861
MRE11	ENSANIP00000009418	ENSANIP00000014353	ENSANIP00000009418	MRE11 homolog, double strand break repair nuclease.	annotation not available	0.861
MRE11	PCNA	ENSANIP00000014353	ENSANIP00000014926	MRE11 homolog, double strand break repair nuclease.	Proliferating cell nuclear antigen.	0.843
MRE11	POLE	ENSANIP00000014353	ENSANIP00000002754	MRE11 homolog, double strand break repair nuclease.	DNA polymerase epsilon, catalytic subunit.	0.844
MRE11	RNASEH2A	ENSANIP00000014353	ENSANIP00000025319	MRE11 homolog, double strand break repair nuclease.	Ribonuclease H2 subunit A.	0.531
MRE11	TDP1	ENSANIP00000014353	ENSANIP00000005970	MRE11 homolog, double strand break repair nuclease.	tyrosyl-DNA phosphodiesterase 1.	0.688
MRE11	TIMELESS	ENSANIP00000014353	ENSANIP00000018446	MRE11 homolog, double strand break repair nuclease.	Timeless circadian regulator.	0.496
MRE11	TOP1MT	ENSANIP00000014353	ENSANIP00000001029	MRE11 homolog, double strand break repair nuclease.	DNA topoisomerase I mitochondrial.	0.863
MRE11	TOP2A	ENSANIP00000014353	ENSANIP00000012869	MRE11 homolog, double strand break repair nuclease.	DNA topoisomerase II alpha.	0.403
MRE11	TOP2B	ENSANIP00000014353	ENSANIP00000007037	MRE11 homolog, double strand break repair nuclease.	DNA topoisomerase II beta.	0.403
PCNA	ENSANIP00000009418	ENSANIP00000014926	ENSANIP00000009418	Proliferating cell nuclear antigen.	annotation not available	0.893