ERICH3 protein (Accipiter nisus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ERICH3

Glutamate rich 3. (1562 aa)

Predicted Functional Partners:

CFAP44

0.780

HLA-DRA

0.642

ENSANIP00000005348

0.638

RHBDL3

0.612

ENSANIP00000020218

0.608

PTK7

0.594

PES1

0.593

ENSANIP00000022618

0.586

ENSANIP00000002394

0.583

WDR18

0.583

Your Current Organism:

Accipiter nisus

NCBI taxonomy Id: 211598
Other names: A. nisus, Eurasian sparrowhawk

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structured XML interaction data, according to the 'PSI-MI' data standard

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CFAP44	ENSANIP00000020218	ENSANIP00000024211	ENSANIP00000020218	Cilia and flagella associated protein 44.	annotation not available	0.725
CFAP44	ERICH3	ENSANIP00000024211	ENSANIP00000007098	Cilia and flagella associated protein 44.	Glutamate rich 3.	0.780
CFAP44	PES1	ENSANIP00000024211	ENSANIP00000011757	Cilia and flagella associated protein 44.	Pescadillo ribosomal biogenesis factor 1.	0.514
ENSANIP00000002394	ENSANIP00000020218	ENSANIP00000002394	ENSANIP00000020218	annotation not available	annotation not available	0.994
ENSANIP00000002394	ERICH3	ENSANIP00000002394	ENSANIP00000007098	annotation not available	Glutamate rich 3.	0.583
ENSANIP00000002394	PES1	ENSANIP00000002394	ENSANIP00000011757	annotation not available	Pescadillo ribosomal biogenesis factor 1.	0.940
ENSANIP00000002394	WDR18	ENSANIP00000002394	ENSANIP00000005169	annotation not available	WD repeat domain 18.	0.899
ENSANIP00000005348	ERICH3	ENSANIP00000005348	ENSANIP00000007098	annotation not available	Glutamate rich 3.	0.638
ENSANIP00000020218	CFAP44	ENSANIP00000020218	ENSANIP00000024211	annotation not available	Cilia and flagella associated protein 44.	0.725
ENSANIP00000020218	ENSANIP00000002394	ENSANIP00000020218	ENSANIP00000002394	annotation not available	annotation not available	0.994
ENSANIP00000020218	ERICH3	ENSANIP00000020218	ENSANIP00000007098	annotation not available	Glutamate rich 3.	0.608
ENSANIP00000020218	PES1	ENSANIP00000020218	ENSANIP00000011757	annotation not available	Pescadillo ribosomal biogenesis factor 1.	0.883
ENSANIP00000020218	WDR18	ENSANIP00000020218	ENSANIP00000005169	annotation not available	WD repeat domain 18.	0.999
ENSANIP00000022618	ERICH3	ENSANIP00000022618	ENSANIP00000007098	annotation not available	Glutamate rich 3.	0.586
ENSANIP00000022618	HLA-DRA	ENSANIP00000022618	ENSANIP00000018542	annotation not available	Major histocompatibility complex, class II, DR alpha.	0.955
ERICH3	CFAP44	ENSANIP00000007098	ENSANIP00000024211	Glutamate rich 3.	Cilia and flagella associated protein 44.	0.780
ERICH3	ENSANIP00000002394	ENSANIP00000007098	ENSANIP00000002394	Glutamate rich 3.	annotation not available	0.583
ERICH3	ENSANIP00000005348	ENSANIP00000007098	ENSANIP00000005348	Glutamate rich 3.	annotation not available	0.638
ERICH3	ENSANIP00000020218	ENSANIP00000007098	ENSANIP00000020218	Glutamate rich 3.	annotation not available	0.608
ERICH3	ENSANIP00000022618	ENSANIP00000007098	ENSANIP00000022618	Glutamate rich 3.	annotation not available	0.586

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.949

expected number of edges:

12

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051123

RNA polymerase II preinitiation complex assembly

8 of 18

2.92

9.32

1.35e-18

GO:0006367

Transcription initiation from RNA polymerase II promoter

9 of 34

2.7

9.28

2.13e-19

GO:0006352

DNA-templated transcription, initiation

10 of 81

2.36

8.24

2.13e-19

GO:0042789

mRNA transcription by RNA polymerase II

8 of 41

2.56

7.65

2.33e-16

GO:0060261

Positive regulation of transcription initiation from RNA polymerase II promoter

8 of 46

2.51

7.42

4.48e-16

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016251

RNA polymerase II general transcription initiation factor activity

5 of 25

2.57

4.39

3.55e-09

GO:0140296

General transcription initiation factor binding

5 of 54

2.24

3.54

6.18e-08

GO:0017025

TBP-class protein binding

4 of 28

2.43

3.15

8.77e-07

GO:0046982

Protein heterodimerization activity

8 of 334

1.65

2.94

2.81e-09

GO:0008134

Transcription factor binding

8 of 636

1.37

1.99

8.87e-08

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005669

Transcription factor TFIID complex

10 of 29

2.81

11.72

3.14e-24

GO:0033276

Transcription factor TFTC complex

6 of 14

2.9

7.14

3.19e-14

GO:0070461

SAGA-type complex

7 of 37

2.55

6.95

8.57e-15

GO:0000124

SAGA complex

4 of 23

2.51

3.73

6.89e-08

GO:0071339

MLL1 complex

4 of 34

2.34

3.35

2.61e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4168

RNA polymerase II preinitiation complex assembly

9 of 10

3.23

12.24

1.25e-23

CL:4125

Transcription factor TFIID complex, and Transcription factor TFIIH holo complex

10 of 34

2.74

11.2

1.63e-23

CL:4172

SLIK (SAGA-like) complex, and Lateral mesoderm formation

5 of 5

3.27

6.35

2.44e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ccan03022

Basal transcription factors

9 of 34

2.7

9.97

5.56e-21

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-76042

RNA Polymerase II Transcription Initiation And Promoter Clearance

9 of 49

2.54

8.68

5.40e-19

MAP-75953

RNA Polymerase II Transcription Initiation

9 of 49

2.54

8.68

5.40e-19

MAP-73779

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

9 of 49

2.54

8.68

5.40e-19

MAP-73776

RNA Polymerase II Promoter Escape

9 of 49

2.54

8.68

5.40e-19

MAP-674695

RNA Polymerase II Pre-transcription Events

9 of 101

2.22

6.9

4.69e-17

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016591

RNA polymerase II, holoenzyme

10 of 64

2.47

9.27

4.03e-21

GOCC:0070461

SAGA-type complex

7 of 34

2.59

7.03

7.63e-15

GOCC:0071339

MLL1 complex

4 of 26

2.46

3.55

1.37e-07

GOCC:0005654

Nucleoplasm

11 of 696

1.47

3.04

1.99e-14

GOCC:1990234

Transferase complex

11 of 858

1.38

2.6

1.71e-13

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

4 of 59

2.1

2.46

1.07e-05

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