node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APH_0051 | dnaE | APH_0051 | APH_1003 | Iron-binding protein; Identified by similarity to GB:AAD03802.1; match to protein family HMM PF01547. | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | 0.549 |
APH_0051 | guaB | APH_0051 | APH_0088 | Iron-binding protein; Identified by similarity to GB:AAD03802.1; match to protein family HMM PF01547. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.612 |
APH_0051 | rnhA | APH_0051 | APH_0109 | Iron-binding protein; Identified by similarity to GB:AAD03802.1; match to protein family HMM PF01547. | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.549 |
APH_0051 | rnhB | APH_0051 | APH_1022 | Iron-binding protein; Identified by similarity to GB:AAD03802.1; match to protein family HMM PF01547. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.595 |
APH_0051 | xerD | APH_0051 | APH_0040 | Iron-binding protein; Identified by similarity to GB:AAD03802.1; match to protein family HMM PF01547. | Tyrosine recombinase XerD; Identified by similarity to SP:P21891; match to protein family HMM PF00589; match to protein family HMM PF02899; Belongs to the 'phage' integrase family. | 0.592 |
APH_1303 | guaB | APH_1303 | APH_0088 | comF family protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.447 |
APH_1303 | xerD | APH_1303 | APH_0040 | comF family protein. | Tyrosine recombinase XerD; Identified by similarity to SP:P21891; match to protein family HMM PF00589; match to protein family HMM PF02899; Belongs to the 'phage' integrase family. | 0.633 |
dnaE | APH_0051 | APH_1003 | APH_0051 | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | Iron-binding protein; Identified by similarity to GB:AAD03802.1; match to protein family HMM PF01547. | 0.549 |
dnaE | guaA | APH_1003 | APH_1233 | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.641 |
dnaE | guaB | APH_1003 | APH_0088 | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.673 |
dnaE | polA | APH_1003 | APH_0001 | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.704 |
dnaE | rnhA | APH_1003 | APH_0109 | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | 0.649 |
dnaE | rnhB | APH_1003 | APH_1022 | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.751 |
dnaE | topA | APH_1003 | APH_0597 | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.620 |
dnaE | xerD | APH_1003 | APH_0040 | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | Tyrosine recombinase XerD; Identified by similarity to SP:P21891; match to protein family HMM PF00589; match to protein family HMM PF02899; Belongs to the 'phage' integrase family. | 0.649 |
guaA | dnaE | APH_1233 | APH_1003 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594. | 0.641 |
guaA | guaB | APH_1233 | APH_0088 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | polA | APH_1233 | APH_0001 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.712 |
guaA | pyrG | APH_1233 | APH_0038 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.989 |
guaA | topA | APH_1233 | APH_0597 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.468 |