Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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ccmAHeme exporter protein CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (206 aa)    
Predicted Functional Partners:
APH_1397
Putative heme exporter protein CcmB.
 
 0.993
ccmC
Heme exporter protein CcmC; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.
 
 0.986
ccmE
Cytochrome c-type biogenesis protein CcmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.
 
 
 0.947
APH_0126
Hypothetical protein; Identified by Glimmer2; putative.
       0.773
APH_0041
ABC transporter, ATP-binding protein; Identified by match to protein family HMM PF00005.
  
     0.745
APH_0687
Cytochrome c biogenesis family protein; Possible subunit of a heme lyase.
 
   
 0.742
APH_0124
Hypothetical protein; Identified by Glimmer2; putative.
       0.682
APH_0141
Putative thiol:disulfide oxidoreductase; Identified by similarity to SP:P33926.
 
   
 0.644
APH_1271
Cytochrome c-type biogenesis protein, CcmF/CycK/CcsA family; Identified by similarity to SP:P45403; match to protein family HMM PF01578.
 
   
 0.558
APH_0157
Putative ABC transporter, ATP-binding protein/permease protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664.
  
    0.492
Your Current Organism:
Anaplasma phagocytophilum
NCBI taxonomy Id: 212042
Other names: A. phagocytophilum str. HZ, Anaplasma phagocytophilum HZ, Anaplasma phagocytophilum str. HZ
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