STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APH_0258ATP-dependent DNA helicase, UvrD/Rep family; Identified by match to protein family HMM PF00580. (788 aa)    
Predicted Functional Partners:
APH_0849
Conserved hypothetical protein; Identified by similarity to GB:AAS14586.1.
 
   
 0.794
recO
DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination.
 
   
 0.788
APH_0903
Helicase, UvrD/Rep family; Identified by match to protein family HMM PF00580.
 
  
 0.770
APH_1214
Identified by match to protein family HMM PF00768; match to protein family HMM PF07943; Belongs to the peptidase S11 family.
      0.694
recF
Putative DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
  
   
 0.694
ligA
DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
  
 
 0.669
APH_0775
Conserved hypothetical protein; Identified by similarity to PIR:E97838; match to protein family HMM PF07031.
  
     0.665
APH_0354
Conserved hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
   
 0.643
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.630
dnaE
DNA polymerase III, alpha subunit; Identified by match to protein family HMM PF02811; match to protein family HMM PF07733; match to protein family HMM TIGR00594.
 
  
 0.629
Your Current Organism:
Anaplasma phagocytophilum
NCBI taxonomy Id: 212042
Other names: A. phagocytophilum str. HZ, Anaplasma phagocytophilum HZ, Anaplasma phagocytophilum str. HZ
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