APH_0353 protein (Anaplasma phagocytophilum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

APH_0353

Metallopeptidase, M24 family; Identified by match to protein family HMM PF00557. (569 aa)

Predicted Functional Partners:

gatA

0.694

guaB

0.581

adk

0.562

APH_0042

0.555

pepA

0.537

pheT

0.503

atpE

0.456

APH_1216

0.452

APH_0659

0.444

map

0.440

Your Current Organism:

Anaplasma phagocytophilum

NCBI taxonomy Id: 212042
Other names: A. phagocytophilum str. HZ, Anaplasma phagocytophilum HZ, Anaplasma phagocytophilum str. HZ

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APH_0042	APH_0353	APH_0042	APH_0353	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	Metallopeptidase, M24 family; Identified by match to protein family HMM PF00557.	0.555
APH_0042	APH_0659	APH_0042	APH_0659	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	Antioxidant, AhpC/Tsa family; Identified by match to protein family HMM PF00578.	0.411
APH_0042	adk	APH_0042	APH_0300	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	0.604
APH_0042	atpE	APH_0042	APH_1191	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	ATP synthase F0, C chain; Identified by match to protein family HMM PF00137.	0.440
APH_0042	pheT	APH_0042	APH_0305	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	phenylalanyl-tRNA synthetase, beta subunit; Identified by similarity to SP:P07395; match to protein family HMM PF01588; match to protein family HMM PF03147; match to protein family HMM PF03483; match to protein family HMM PF03484; match to protein family HMM TIGR00472; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.	0.610
APH_0353	APH_0042	APH_0353	APH_0042	Metallopeptidase, M24 family; Identified by match to protein family HMM PF00557.	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	0.555
APH_0353	APH_0659	APH_0353	APH_0659	Metallopeptidase, M24 family; Identified by match to protein family HMM PF00557.	Antioxidant, AhpC/Tsa family; Identified by match to protein family HMM PF00578.	0.444
APH_0353	APH_1216	APH_0353	APH_1216	Metallopeptidase, M24 family; Identified by match to protein family HMM PF00557.	polyA polymerase/tRNA nucleotidyltransferase family protein; Identified by similarity to SP:P42977; match to protein family HMM PF01743; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.	0.452
APH_0353	adk	APH_0353	APH_0300	Metallopeptidase, M24 family; Identified by match to protein family HMM PF00557.	Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	0.562
APH_0353	atpE	APH_0353	APH_1191	Metallopeptidase, M24 family; Identified by match to protein family HMM PF00557.	ATP synthase F0, C chain; Identified by match to protein family HMM PF00137.	0.456
APH_0353	gatA	APH_0353	APH_0748	Metallopeptidase, M24 family; Identified by match to protein family HMM PF00557.	glutamyl-tRNA(Gln) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln).	0.694
APH_0353	guaB	APH_0353	APH_0088	Metallopeptidase, M24 family; Identified by match to protein family HMM PF00557.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.581
APH_0353	map	APH_0353	APH_1199	Metallopeptidase, M24 family; Identified by match to protein family HMM PF00557.	Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	0.440
APH_0353	pepA	APH_0353	APH_0231	Metallopeptidase, M24 family; Identified by match to protein family HMM PF00557.	Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.	0.537
APH_0353	pheT	APH_0353	APH_0305	Metallopeptidase, M24 family; Identified by match to protein family HMM PF00557.	phenylalanyl-tRNA synthetase, beta subunit; Identified by similarity to SP:P07395; match to protein family HMM PF01588; match to protein family HMM PF03147; match to protein family HMM PF03483; match to protein family HMM PF03484; match to protein family HMM TIGR00472; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.	0.503
APH_0659	APH_0042	APH_0659	APH_0042	Antioxidant, AhpC/Tsa family; Identified by match to protein family HMM PF00578.	Malate dehydrogenase; Identified by similarity to SP:O30808; match to protein family HMM PF00390; match to protein family HMM PF01515; match to protein family HMM PF03949.	0.411
APH_0659	APH_0353	APH_0659	APH_0353	Antioxidant, AhpC/Tsa family; Identified by match to protein family HMM PF00578.	Metallopeptidase, M24 family; Identified by match to protein family HMM PF00557.	0.444
APH_0659	guaB	APH_0659	APH_0088	Antioxidant, AhpC/Tsa family; Identified by match to protein family HMM PF00578.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.447
APH_1216	APH_0353	APH_1216	APH_0353	polyA polymerase/tRNA nucleotidyltransferase family protein; Identified by similarity to SP:P42977; match to protein family HMM PF01743; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.	Metallopeptidase, M24 family; Identified by match to protein family HMM PF00557.	0.452
APH_1216	pheT	APH_1216	APH_0305	polyA polymerase/tRNA nucleotidyltransferase family protein; Identified by similarity to SP:P42977; match to protein family HMM PF01743; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.	phenylalanyl-tRNA synthetase, beta subunit; Identified by similarity to SP:P07395; match to protein family HMM PF01588; match to protein family HMM PF03147; match to protein family HMM PF03483; match to protein family HMM PF03484; match to protein family HMM TIGR00472; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.	0.560