STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APH_0354Conserved hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (230 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.995
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.949
hemB
Delta-aminolevulinic acid dehydratase; Identified by similarity to SP:P45622; match to protein family HMM PF00490; Belongs to the ALAD family.
  
 
 0.899
APH_0956
Identified by match to protein family HMM PF02325.
 
     0.696
holA
DNA polymerase III, delta subunit; Identified by similarity to GB:AAS14093.1; match to protein family HMM PF06144.
 
     0.690
APH_0258
ATP-dependent DNA helicase, UvrD/Rep family; Identified by match to protein family HMM PF00580.
  
   
 0.643
APH_0849
Conserved hypothetical protein; Identified by similarity to GB:AAS14586.1.
  
     0.637
APH_0775
Conserved hypothetical protein; Identified by similarity to PIR:E97838; match to protein family HMM PF07031.
  
     0.615
APH_0110
Acetamidase/formamidase family protein.
  
     0.603
ccmC
Heme exporter protein CcmC; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.
  
    0.589
Your Current Organism:
Anaplasma phagocytophilum
NCBI taxonomy Id: 212042
Other names: A. phagocytophilum str. HZ, Anaplasma phagocytophilum HZ, Anaplasma phagocytophilum str. HZ
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