| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APH_0275 | APH_0362 | APH_0275 | APH_0362 | RNA methyltransferase, TrmH family, group 3; Identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosomal large subunit pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | 0.770 |
| APH_0275 | rplC | APH_0275 | APH_0280 | RNA methyltransferase, TrmH family, group 3; Identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.894 |
| APH_0275 | rplO | APH_0275 | APH_0298 | RNA methyltransferase, TrmH family, group 3; Identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. | 0.855 |
| APH_0275 | rplQ | APH_0275 | APH_0304 | RNA methyltransferase, TrmH family, group 3; Identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosomal protein L17; Identified by similarity to SP:P02416; match to protein family HMM PF01196; match to protein family HMM TIGR00059. | 0.842 |
| APH_0275 | rplS | APH_0275 | APH_1266 | RNA methyltransferase, TrmH family, group 3; Identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.729 |
| APH_0275 | rplT | APH_0275 | APH_0060 | RNA methyltransferase, TrmH family, group 3; Identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | 0.699 |
| APH_0275 | rplU | APH_0275 | APH_0697 | RNA methyltransferase, TrmH family, group 3; Identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.826 |
| APH_0275 | rsfS | APH_0275 | APH_0207 | RNA methyltransferase, TrmH family, group 3; Identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | Iojap-related protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.814 |
| APH_0275 | trmE | APH_0275 | APH_1288 | RNA methyltransferase, TrmH family, group 3; Identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.798 |
| APH_0362 | APH_0275 | APH_0362 | APH_0275 | Ribosomal large subunit pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | RNA methyltransferase, TrmH family, group 3; Identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | 0.770 |
| APH_0362 | obg | APH_0362 | APH_0694 | Ribosomal large subunit pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | GTP-binding protein, GTP1/Obg family; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | 0.808 |
| APH_0362 | rplC | APH_0362 | APH_0280 | Ribosomal large subunit pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. | 0.759 |
| APH_0362 | rplO | APH_0362 | APH_0298 | Ribosomal large subunit pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. | 0.755 |
| APH_0362 | rplQ | APH_0362 | APH_0304 | Ribosomal large subunit pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | Ribosomal protein L17; Identified by similarity to SP:P02416; match to protein family HMM PF01196; match to protein family HMM TIGR00059. | 0.766 |
| APH_0362 | rplS | APH_0362 | APH_1266 | Ribosomal large subunit pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | Ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.760 |
| APH_0362 | rplT | APH_0362 | APH_0060 | Ribosomal large subunit pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. | 0.768 |
| APH_0362 | rplU | APH_0362 | APH_0697 | Ribosomal large subunit pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.761 |
| APH_0362 | rsfS | APH_0362 | APH_0207 | Ribosomal large subunit pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | Iojap-related protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.773 |
| APH_0362 | trmE | APH_0362 | APH_1288 | Ribosomal large subunit pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.782 |
| obg | APH_0362 | APH_0694 | APH_0362 | GTP-binding protein, GTP1/Obg family; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. | Ribosomal large subunit pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. | 0.808 |
