| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APH_0351 | APH_0471 | APH_0351 | APH_0471 | Conserved hypothetical protein; Identified by similarity to GB:AAS14435.1. | Exodeoxyribonuclease III, N-terminal truncated; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00633. | 0.553 |
| APH_0351 | dnaN | APH_0351 | APH_1097 | Conserved hypothetical protein; Identified by similarity to GB:AAS14435.1. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.972 |
| APH_0351 | nth | APH_0351 | APH_0897 | Conserved hypothetical protein; Identified by similarity to GB:AAS14435.1. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.509 |
| APH_0351 | polA | APH_0351 | APH_0001 | Conserved hypothetical protein; Identified by similarity to GB:AAS14435.1. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.971 |
| APH_0351 | rnhB | APH_0351 | APH_1022 | Conserved hypothetical protein; Identified by similarity to GB:AAS14435.1. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.763 |
| APH_0351 | xth | APH_0351 | APH_0505 | Conserved hypothetical protein; Identified by similarity to GB:AAS14435.1. | Exodeoxyribonuclease III; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633. | 0.553 |
| APH_0471 | APH_0351 | APH_0471 | APH_0351 | Exodeoxyribonuclease III, N-terminal truncated; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00633. | Conserved hypothetical protein; Identified by similarity to GB:AAS14435.1. | 0.553 |
| APH_0471 | dnaN | APH_0471 | APH_1097 | Exodeoxyribonuclease III, N-terminal truncated; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00633. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.874 |
| APH_0471 | dut | APH_0471 | APH_0379 | Exodeoxyribonuclease III, N-terminal truncated; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00633. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.501 |
| APH_0471 | nth | APH_0471 | APH_0897 | Exodeoxyribonuclease III, N-terminal truncated; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00633. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.883 |
| APH_0471 | polA | APH_0471 | APH_0001 | Exodeoxyribonuclease III, N-terminal truncated; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00633. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.814 |
| APH_0471 | rnhB | APH_0471 | APH_1022 | Exodeoxyribonuclease III, N-terminal truncated; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00633. | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.540 |
| APH_0471 | xth | APH_0471 | APH_0505 | Exodeoxyribonuclease III, N-terminal truncated; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00633. | Exodeoxyribonuclease III; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633. | 0.900 |
| dnaN | APH_0351 | APH_1097 | APH_0351 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Conserved hypothetical protein; Identified by similarity to GB:AAS14435.1. | 0.972 |
| dnaN | APH_0471 | APH_1097 | APH_0471 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Exodeoxyribonuclease III, N-terminal truncated; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00633. | 0.874 |
| dnaN | dut | APH_1097 | APH_0379 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.857 |
| dnaN | polA | APH_1097 | APH_0001 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.995 |
| dnaN | rnhB | APH_1097 | APH_1022 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.887 |
| dnaN | xth | APH_1097 | APH_0505 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Exodeoxyribonuclease III; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633. | 0.874 |
| dut | APH_0471 | APH_0379 | APH_0471 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Exodeoxyribonuclease III, N-terminal truncated; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00633. | 0.501 |
